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Analysis of bioactive components and pharmacokinetic study of herb–herb interactions in the traditional Chinese patent medicine Tongmai Yangxin Pill
- Source :
- Journal of Pharmaceutical and Biomedical Analysis. 120:364-373
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Tongmai Yangxin (TMYX) Pill is a traditional Chinese patent medicine, composed of eleven Chinese medicinal herbs. It has been used to treat coronary heart disease for several decades. In this study, six male Sprague-Dawley rats were dosed orally with TMYX methanol extract, and a serum pharmacochemistry technique was used to screen absorbed bioactive compounds by UPLC/Q-TOF-MS. By comparing MS spectra to the published literature data, 40 bioactive components were identified. The results indicated that almost 45% of the absorbed compounds were from Radix Glycyrrhizae (GC). Subsequently, a reliable HPLC method was used to determine the concentrations of liquiritin, liquiritigenin, isoliquiritigenin, glycyrrhizic acid, and glycyrrhetinic acid in rat plasma following oral administration of GC or the combination of GC and Ramulus Cinnamomi (GZ). The results showed that GZ enhanced the absorption of four bioactive components: liquiritigenin, isoliquiritigenin, glycyrrhizic acid, and glycyrrhetinic acid. The data demonstrate that herb combination in TMYX Pill exhibit a synergistic action.
- Subjects :
- Male
food.ingredient
Chinese patent medicine
Clinical Biochemistry
Herb-Drug Interactions
Pharmaceutical Science
Pharmacology
01 natural sciences
High-performance liquid chromatography
Analytical Chemistry
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
food
Pharmacokinetics
Tandem Mass Spectrometry
Oral administration
Drug Discovery
Animals
Medicine, Chinese Traditional
Chromatography, High Pressure Liquid
Spectroscopy
010401 analytical chemistry
Rats
0104 chemical sciences
chemistry
030220 oncology & carcinogenesis
Herb
Liquiritigenin
Isoliquiritigenin
Liquiritin
Drugs, Chinese Herbal
Subjects
Details
- ISSN :
- 07317085
- Volume :
- 120
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmaceutical and Biomedical Analysis
- Accession number :
- edsair.doi.dedup.....e501e1c4888518ed2dcaf586c58de7c8