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Amoxicillin Pharmacokinetics in Pregnant Women: Modeling and Simulations of Dosage Strategies
- Source :
- Clinical Pharmacology & Therapeutics. 81:547-556
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- Amoxicillin is recommended for anthrax prevention in pregnancy. The objective of this study was to evaluate the pharmacokinetics of amoxicillin during pregnancy and postpartum (PP). Sixteen women received amoxicillin during gestation (18-22 weeks (T2) and 30-34 weeks (T3)) as well as 3 months postpartum (PP) to evaluate single-dose pharmacokinetics. Amoxicillin compartmental pharmacokinetic parameters were used to simulate amoxicillin concentration-time profiles following different dosage strategies. Amoxicillin CL(renal) (T2: 24.8+/-6.7 l/h, P
- Subjects :
- Adult
Adolescent
medicine.drug_class
Pregnancy Trimester, Third
Antibiotics
Penicillins
Pharmacology
Pharmacokinetics
Pregnancy
Area under curve
medicine
Humans
Computer Simulation
Pharmacology (medical)
Models, Statistical
Reabsorption
business.industry
Extramural
Amoxicillin
Middle Aged
medicine.disease
Area Under Curve
Pregnancy Trimester, Second
Gestation
Female
business
Monte Carlo Method
Algorithms
medicine.drug
Subjects
Details
- ISSN :
- 15326535 and 00099236
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Clinical Pharmacology & Therapeutics
- Accession number :
- edsair.doi.dedup.....e5006f0b994103d133a78da95c303a6f