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Interleukin-6: a possible inflammatory link between vitiligo and type 1 diabetes
- Source :
- British journal of biomedical science. 71(4)
- Publication Year :
- 2015
-
Abstract
- Vitiligo is a pigmentation disorder of unknown aetiology, but it has been reported in association with other autoimmune diseases including type 1 diabetes mellitus (T1D). Vitiligo and T1D share a common theory of autoimmunity, but still an inflammatory link between them remains to be investigated. This study investigates the status and contribution of the inflammatory markers tumour necrosis factor-α (TNFα), interleukin (IL)-6 and IL-1 in patients with vitiligo, T1D and vitiligo-associated T1D (Vt-T1D). The data showed that sera from Vt-T1D patients (n = 21) had higher levels of TNFα, IL-6 and IL-1β compared with vitiligo patients (n = 39), T1D patients (n = 37) or controls (n = 42). Interestingly, serum levels of IL-6 were found to be significantly higher in Vt-T1D patients compared with the levels of TNFα and IL-1β. These data also showed that IL-6 was high in Vt patients as compared to the levels of TNFa and L-1β, whereas in T1D patients, IL-6 and TNFα were almost the same but were higher than IL-1β. In conclusion, this is the first study to show an inflammatory link between vitiligo and T1D. The data conclude that IL-6 plays an important role in the pathogenesis of Vt-T1D patients and is likely to gain favour as a therapeutic target in these patients.
- Subjects :
- Microbiology (medical)
Adult
Male
endocrine system
endocrine system diseases
Adolescent
Clinical Biochemistry
Immunology
Interleukin-1beta
Vitiligo
Inflammation
medicine.disease_cause
Microbiology
Autoimmunity
Pathogenesis
Young Adult
immune system diseases
Diabetes mellitus
Immunology and Allergy
Medicine
Humans
Interleukin 6
Child
Type 1 diabetes
biology
business.industry
Interleukin-6
Tumor Necrosis Factor-alpha
Biochemistry (medical)
nutritional and metabolic diseases
Interleukin
Middle Aged
medicine.disease
Peptide Fragments
Infectious Diseases
Diabetes Mellitus, Type 1
biology.protein
Female
medicine.symptom
Inflammation Mediators
business
Biomarkers
Subjects
Details
- ISSN :
- 09674845
- Volume :
- 71
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- British journal of biomedical science
- Accession number :
- edsair.doi.dedup.....e4fcdcc0e10706c1e791cb1ec58bd79e