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The role of antagonists of the PD-1:PD-L1/PD-L2 axis in head and neck cancer treatment
- Source :
- Oral oncology. 61
- Publication Year :
- 2016
-
Abstract
- We review the current clinical knowledge surrounding one of the most promising immune checkpoint pathways currently investigated in head and neck squamous cell carcinoma patients, programmed cell death-1 (PD-1) and its ligands (PD-L1 and PD-L2). We review ongoing clinical trials and associated clinical responses observed with targeting the receptor, PD-1, and its ligand, PD-L1. A recent phase III clinical trial (Checkmate 141) demonstrated an improved overall survival in head and neck cancer patients treated with anti-PD-1 monotherapy as compared to standard of care for recurrent and/or metastatic disease, which raises questions on how best to incorporate immunotherapy in the context of standard of care. We discuss biomarkers of response to this class of novel drugs, which is an area of active investigation. Lastly, we project future directions in the field wherein understanding how the Fc portions of the various monoclonal antibodies may impact their clinical efficacy as well as discuss areas where our next advances may take place, such as combination strategies.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Context (language use)
Disease
Article
B7-H1 Antigen
03 medical and health sciences
0302 clinical medicine
PD-L1
Internal medicine
medicine
Tumor Microenvironment
Humans
biology
business.industry
Head and neck cancer
Immunotherapy
medicine.disease
Programmed Cell Death 1 Ligand 2 Protein
Head and neck squamous-cell carcinoma
Immune checkpoint
Clinical trial
030104 developmental biology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Immunology
biology.protein
Oral Surgery
business
Subjects
Details
- ISSN :
- 18790593
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Oral oncology
- Accession number :
- edsair.doi.dedup.....e4e89e27b5b2b248222b87ced6c54cf2