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Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity
- Source :
- Journal of pharmaceutical sciences. 94(4)
- Publication Year :
- 2005
-
Abstract
- Terahertz pulsed spectroscopy (TPS) is a new technique that is capable of eliciting rich information when investigating pharmaceutical materials. In solids, it probes long-range crystalline lattice vibrations and low energy torsion and hydrogen bonding vibrations. These properties make TPS potentially an ideal tool to investigate crystallinity and polymorphism. In this study four drugs with different solid-state properties were analyzed using TPS and levels of polymorphism and crystallinity were quantified. Carbamazepine and enalapril maleate polymorphs, amorphous, and crystalline indomethacin, and thermotropic liquid crystalline and crystalline fenoprofen calcium mixtures were quantified using partial least-squares analysis. Root-mean-squared errors of cross validation as low as 0.349% and limits of detection as low as approximately 1% were obtained, demonstrating that TPS is an analytical technique of potential in quantifying solid-state properties of pharmaceutical compounds.
- Subjects :
- Chemical Phenomena
Indomethacin
Analytical chemistry
Pharmaceutical Science
Infrared spectroscopy
Crystal structure
Thermotropic crystal
Crystallinity
Enalapril
Isomerism
Fenoprofen
medicine
Organic chemistry
Least-Squares Analysis
Spectroscopy
Chemistry
Chemistry, Physical
Spectrum Analysis
Reproducibility of Results
eye diseases
Amorphous solid
Drug Combinations
Carbamazepine
Polymorphism (materials science)
Pharmaceutical Preparations
sense organs
Powders
Crystallization
medicine.drug
Subjects
Details
- ISSN :
- 00223549
- Volume :
- 94
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of pharmaceutical sciences
- Accession number :
- edsair.doi.dedup.....e4e296f5fd2e1eda0315c61297687a90