Griseofulvin, Diketopiperazines and Cytochalasins from Endophytic Fungi Colletotrichum crassipes and Xylaria sp., and Their Antifungal, Antioxidant and Anticholinesterase Activities

Made available in DSpace on 2018-12-11T17:37:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-08-01. Added 1 bitstream(s) on 2019-10-09T18:33:16Z : No. of bitstreams: 1 S0103-50532018000801707.pdf: 605856 bytes, checksum: d0e7f35c91ac7a98ee81f395b5893fb3 (MD5) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) One new natural product, 1-phenylethyl-O-α-L-rhamnopyranoside, together with eight known diketopiperazines and two benzene derivatives were isolated from the endophytic fungus Colletotrichum crassipes, whereas six known compounds including two griseofulvins, three cytochalasins and one dihydroisocoumarin were produced from the endophyte Xylaria sp., both endophytic fungi are associated with leaves of Casearia sylvestris. Cyclo(D)-Pro-(D)-Phe, N-(2-phenylethyl)acetamide and 5-carboxy-6-hydroxy-3-methyl-3,4-dihydroisocoumarin exhibited potent antifungal activity against Cladosporium cladosporioides and C. sphaerospermum. The compounds cyclo(D)-Pro-(D)-Phe, griseofulvin, cytochalasin B and cytochalasin D exhibited antioxidant activity, and the compounds cyclo(D)-Pro-(D)-Phe, cytochalasin B and cytochalasin C showed potent acetylcholinesterase (AChE) inhibition. In addition, this is the first report on the isolation of secondary metabolites from two endophytic fungal strains, associated with Casearia sylvestris. Printed in Brazil- Núcleo de Bioensaios Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE) Instituto de Química Universidade Estadual Paulista (Unesp) Curso de Química Ambiental Universidade Federal Do Tocantins (UFT) Laboratório de Fitoquímica e Biomoléculas (LabFitoBio) Departamento de Química Universidade Estadual de Londrina (UEL) Instituto de Ciências Exatas e Tecnológicas Universidade Federal de Viçosa Seção de Fisiologia e Bioquímica de Plantas Instituto de Botânica Departamento de Fitopatologia Universidade Federal de Lavras Núcleo de Bioensaios Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE) Instituto de Química Universidade Estadual Paulista (Unesp) FAPESP: 2011/03017-6