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Arterial lesions in repeatedly bred spontaneously hypertensive rats
- Source :
- Circulation Research. 38:494-501
- Publication Year :
- 1976
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1976.
-
Abstract
- Repeatedly bred male and female rats of many strains develop hyperglycemia, hyperlipidemia, hypertension, and arteriosclerosis spontaneously. The intensity of their arterial disease and related metabolic derangements appear to be related to their reproductive activity. Repeatedly bred spontaneously hypertensive rats (SHR) were found to have severe hypertension, hyperglycemia, hyperlipidemia, elevated creatine phosphokinase (CPK), serum glutamic oxaloacetic and glutamic pyruvic transaminase (SGOT, SGPT), and lactic dehydrogenase (LDH), as well as high circulating corticosterone levels. Despite these atherogenic metabolic derangements and their severe hypertension, the breeder SHR did not develop the severe, generalized arteriosclerosis found in other strains of breeder rats. Instead, the arterial lesions, consisting of intimal hyalinization and fibrosis, medial hypertrophy, and occlusion of the lumen, were found only in male breeder SHR and were confined to the intratubular arteries of the testes. It is suggested that the severe hypertension, genetic influences, or differences in hypothalamic-pituitary-adrenal-gonadal function in breeder SHR may not have been conducive to the development of arteriosclerosis in this particular strain of rats.
- Subjects :
- Male
medicine.medical_specialty
Adrenocortical Hyperfunction
Arteriosclerosis
Physiology
Lumen (anatomy)
Hyperlipidemias
Blood Urea Nitrogen
chemistry.chemical_compound
Sex Factors
Corticosterone
Fibrosis
Internal medicine
Adrenal Glands
Occlusion
Hyperlipidemia
medicine
Animals
Aspartate Aminotransferases
Creatine Kinase
Hyaline
biology
business.industry
Alanine Transaminase
Rats, Inbred Strains
Arteries
medicine.disease
Rats
Disease Models, Animal
Endocrinology
chemistry
Hyperglycemia
Hypertension
biology.protein
Female
Creatine kinase
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15244571 and 00097330
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Circulation Research
- Accession number :
- edsair.doi.dedup.....e4bebf1559b2b64c669759ad28d819fd