Brain Impairment revealed by Multi-Modality MRI in Parkinson’s Disease

ObjectiveTo study the abnormal brain regions of patients with Parkinson’s disease (PD) using multimodality MRI to provide complementary information for early detection for PD.Methods27 patients with early PD and 25 normal ageing volunteers were included in the study. Multimodality MRI data were acquired and processed to extract neuroimaging features to test the structural and functional changes using a two-sample t-test.ResultsThe changes of brain regions were disagreed for different modality MRI data between PD and normal ageing individuals. Nevertheless,the postcentral gyrus, precentral gyrus, lingual gyrus and paracentral lobule were significantly different for all three modalities.ConclusionMultimodality MRI data can reflect the structural and functional changes of PD, and reveal the hidden information which is of great significance to assist early detection for PD.