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Diagnostic value of using a combination of nucleic acid and specific antibody tests for SARS-CoV-2 in coronavirus disease 2019
- Source :
- Epidemiology and Infection
- Publication Year :
- 2021
- Publisher :
- Cambridge University Press (CUP), 2021.
-
Abstract
- Coronavirus disease 2019 (COVID-19) is a newly emerged disease with various clinical manifestations and imaging features. The diagnosis of COVID-19 depends on a positive nucleic acid amplification test by real-time reverse transcription-polymerase chain reaction (RT-PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the clinical manifestations and imaging features of COVID-19 are non-specific, and nucleic acid test for SARS-CoV-2 can have false-negative results. It is presently believed that detection of specific antibodies to SARS-CoV-2 is an effective screening and diagnostic indicator for SARS-CoV-2 infection. Thus, a combination of nucleic acid and specific antibody tests for SARS-CoV-2 will be more effective to diagnose COVID-19, especially to exclude suspected cases.
- Subjects :
- Adult
0301 basic medicine
Coronavirus disease 2019 (COVID-19)
Epidemiology
viruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Review
Disease
Antibodies, Viral
Diagnosis, Differential
Young Adult
03 medical and health sciences
COVID-19 Testing
0302 clinical medicine
Pneumonia, Bacterial
medicine
Humans
030212 general & internal medicine
skin and connective tissue diseases
Lung
Antibody
medicine.diagnostic_test
biology
SARS-CoV-2
business.industry
fungi
COVID-19
virus diseases
Nucleic acid test
Virology
Anti-Bacterial Agents
COVID-19 Drug Treatment
nucleic acid
body regions
Specific antibody
Treatment Outcome
030104 developmental biology
Infectious Diseases
Nucleic acid
biology.protein
RNA, Viral
Female
Differential diagnosis
business
Subjects
Details
- ISSN :
- 14694409 and 09502688
- Volume :
- 149
- Database :
- OpenAIRE
- Journal :
- Epidemiology and Infection
- Accession number :
- edsair.doi.dedup.....e4b4342fb91db804569b52dd45eaacf5