Back to Search
Start Over
Hippocampal Glutathione Depletion and pH Increment in Alzheimer’s Disease: An in vivo MRS Study
- Source :
- Journal of Alzheimer's Disease. 84:1139-1152
- Publication Year :
- 2021
- Publisher :
- IOS Press, 2021.
-
Abstract
- Background: Oxidative stress plays a major role in Alzheimer’s disease (AD) pathogenesis, and thus, antioxidant glutathione (GSH) has been actively investigated in mitigating the oxidative load. Significant hippocampal GSH depletion has been correlated with cognitive impairment in AD. Furthermore, postmortem studies indicated alterations in cellular-energy metabolism and hippocampal pH change toward alkalinity in AD. Objective: Concurrent analysis of hippocampal GSH and pH interplay in vivo on the same individual is quite unclear and hence requires investigation to understand the pathological events in AD. Methods: Total 39 healthy old (HO), 22 mild cognitive impairment (MCI), and 37 AD patients were recruited for hippocampal GSH using 1H-MRS MEGA-PRESS and pH using 2D 31P-MRSI with dual tuned (1H/31P) transmit/receive volume head coil on 3T-Philips scanner. All MRS data processing using KALPANA package and statistical analysis were performed MedCalc, respectively and NINS-STAT package. Results: Significant GSH depletion in the left and right hippocampus (LH and RH) among MCI and AD study groups as compared to HO was observed, whereas pH increased significantly in the LH region between HO and AD. Hippocampal GSH level negatively correlated with pH in both patient groups. The ROC analysis on the combined effect of GSH and pH in both hippocampal regions give accuracy for MCI (LH: 78.27%; RH: 86.96%) and AD (LH: 88%; RH: 78.26%) groups differentiating from HO. Conclusion: Outcomes from this study provide further insights to metabolic alterations in terms of concurrent assessment of hippocampal GSH and pH levels in AD pathogenesis, aiding in early diagnosis of MCI and AD.
- Subjects :
- Male
medicine.medical_specialty
Postmortem studies
Magnetic Resonance Spectroscopy
Antioxidant
Proton Magnetic Resonance Spectroscopy
medicine.medical_treatment
Hippocampal formation
medicine.disease_cause
Hippocampus
Pathogenesis
chemistry.chemical_compound
Alzheimer Disease
In vivo
Internal medicine
medicine
Humans
Hippocampus (mythology)
Cognitive Dysfunction
Aged
business.industry
General Neuroscience
General Medicine
Glutathione
Hydrogen-Ion Concentration
Oxidative Stress
Psychiatry and Mental health
Clinical Psychology
Endocrinology
chemistry
Female
Geriatrics and Gerontology
business
Oxidative stress
Subjects
Details
- ISSN :
- 18758908 and 13872877
- Volume :
- 84
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's Disease
- Accession number :
- edsair.doi.dedup.....e4a6911c1f6394d61aa5742452d8d0b0