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Cycloheximide impairs and enhances memory depending on dose and footshock intensity
- Source :
- Behavioural Brain Research. 233:293-297
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- This experiment examined the effects on memory of interactions of cycloheximide dose and training foot shock intensity. Mice received injections of cycloheximide (120 mg/kg, s.c.) or saline 30 min prior to inhibitory avoidance training with shock intensities of 100, 150, 250 or 300 µA (1 sec duration). Memory was tested 48 hr later. The saline control mice showed increasing memory latencies as a function of shock intensity. The ability of cycloheximide to impair memory increased as the training shock intensity increased. In a second experiment, mice were trained with a 200 µA (1 sec duration) shock and received injections of saline or cycloheximide at one of several doses (30, 60 or 120 mg/kg). Under these training conditions, cycloheximide enhanced memory in an inverted-U dose-response manner. These findings are consistent with prior findings suggesting that protein synthesis inhibitors act on memory by altering modulators of memory formation as a secondary consequence of the inhibition of protein synthesis rather than by interfering with training-initiated synthesis of proteins required for memory formation.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Biophysics
Cycloheximide
Inhibitory postsynaptic potential
Article
Mice
Behavioral Neuroscience
chemistry.chemical_compound
Internal medicine
Avoidance Learning
Reaction Time
Protein biosynthesis
medicine
Animals
Saline
Protein Synthesis Inhibitors
Electroshock
Memory Disorders
Mice, Inbred ICR
Protein synthesis inhibitor
Long-term memory
Intensity (physics)
Disease Models, Animal
Endocrinology
chemistry
Shock (circulatory)
medicine.symptom
Subjects
Details
- ISSN :
- 01664328
- Volume :
- 233
- Database :
- OpenAIRE
- Journal :
- Behavioural Brain Research
- Accession number :
- edsair.doi.dedup.....e4a42218c1af30918c4ecbd0e12ff9db