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Anxiety in Late-Life Depression: Determinants of the Course of Anxiety and Complete Remission
- Source :
- American Journal of Geriatric Psychiatry, 29(4), 336-347. ELSEVIER SCIENCE INC, American Journal of Geriatric Psychiatry, 29(4), 336-347. Elsevier Science
- Publication Year :
- 2021
-
Abstract
- OBJECTIVE: Studies on the course of depression often ignore comorbid anxiety disorders or anxiety symptoms. We explored predictors of complete remission (no depression nor anxiety diagnoses at follow-up) and of the course of comorbid anxiety symptoms. We additionally tested the hypothesis that the course of anxiety disorders and symptoms in depressed patients is explained by negative life-events in the presence of high neuroticism or a low sense of mastery.METHODS: An observational study of 270 patients (≥60 years) diagnosed with major depressive disorder and 2-year follow-up data, who participated in the Netherlands Study of Depression in Older persons (NESDO). Sociodemographic, somatic, psychiatric, and treatment variables were first explored as possible predictors. A multiple logistic regression analysis was used to examine their predictive value concerning complete remission. Subsequently, negative life-events, personality and their interaction were tested as potential predictors. Linear Mixed Models were used to assess whether the personality traits modified the effect of early and recent life-events, and time and their interactions on the course of the anxiety symptoms.RESULTS: A total of 135 of 270 patients achieved complete remission. Depressed patients with a comorbid anxiety disorder at baseline less often achieved complete remission: 38 of 103 (37.0%) versus 97 of 167 (58.1%). The severity of depressive and anxiety symptomatology, the presence of a comorbid anxiety disorder, and a poorer physical health at baseline predicted nonremission. In line with our hypothesis, a less favorable course of self-reported anxiety symptoms was associated with more recent negative life-events, but only among patients with a high level of neuroticism or a low level of mastery.CONCLUSION: Comorbid anxiety in depression as a negative impact on complete remission at 2-year follow-up. The course of anxiety severity seems dependent on the interaction of personality traits and life-events.
- Subjects :
- Male
media_common.quotation_subject
Comorbidity
Anxiety
Life Change Events
late-life depression
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Personality
Big Five personality traits
Depression (differential diagnoses)
Aged
Netherlands
media_common
Aged, 80 and over
Neuroticism
Depressive Disorder, Major
030214 geriatrics
business.industry
Comorbid anxiety
Remission Induction
Middle Aged
Late life depression
Prognosis
medicine.disease
Anxiety Disorders
negative life events
Psychiatry and Mental health
personality
Major depressive disorder
Female
Observational study
Self Report
Geriatrics and Gerontology
medicine.symptom
business
Clinical psychology
Subjects
Details
- Language :
- English
- ISSN :
- 10647481
- Volume :
- 29
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- American Journal of Geriatric Psychiatry
- Accession number :
- edsair.doi.dedup.....e48fcb7261e2ff3f9b433d27f8619af7