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Total and High Molecular Weight But Not Trimeric or Hexameric Forms of Adiponectin Correlate with Markers of the Metabolic Syndrome and Liver Injury in Thai Subjects
- Source :
- The Journal of Clinical Endocrinology & Metabolism. 92:4313-4318
- Publication Year :
- 2007
- Publisher :
- The Endocrine Society, 2007.
-
Abstract
- Decreased total adiponectin has been associated with metabolic disorders, including obesity, diabetes, fatty liver, and the metabolic syndrome. Although circulating adiponectin is composed of trimers, hexamers, and high molecular weight (HMW) multimers, there has been limited study of the specific metabolic correlates of these isoforms in humans. Thus, our objective was to evaluate the associations of these adiponectin isoforms with metabolic and anthropometric parameters.A total of 53 diabetic and 68 nondiabetic subjects attending outpatient clinics underwent cross-sectional metabolic characterization. Circulating levels of HMW, hexameric, and trimeric adiponectin were measured using a multimeric adiponectin ELISA based upon selective protease-mediated digestion.On Spearman univariate analysis, both total and HMW adiponectin levels were inversely associated with body mass index, fasting glucose, homeostasis model of assessment of insulin resistance, triglycerides, and alanine aminotransferase (ALT) (all |r|or= 0.22; P0.05), with the HMW isoform also positively correlated with high-density lipoprotein cholesterol (r = 0.19; P = 0.036). In contrast, hexameric and trimeric adiponectin were significantly associated with only body mass index (r = -0.23; P = 0.0102) and mid-upper arm circumference (r = 0.21; P = 0.039), respectively. On separate forward stepwise multiple linear regression analyses, fasting glucose and ALT emerged as independent, negative covariates of both total and HMW adiponectin, whereas no independent covariates of hexameric and trimeric adiponectin were identified. Furthermore, after adjustment for age, gender, and diabetes, mean ALT was highest in subjects in the lowest tertile of HMW adiponectin, followed in turn by the middle and highest tertiles, respectively (trend P = 0.028).HMW adiponectin, but not hexameric or trimeric, tracks with the metabolic correlates of total adiponectin. Furthermore, an independent inverse association exists between ALT and HMW adiponectin.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Polymers
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Clinical Biochemistry
Enzyme-Linked Immunosorbent Assay
Context (language use)
Biochemistry
Body Mass Index
Cohort Studies
Endocrinology
Insulin resistance
Risk Factors
Internal medicine
Diabetes mellitus
Diabetes Mellitus
medicine
Humans
Outpatient clinic
Metabolic Syndrome
Anthropometry
Adiponectin
Waist-Hip Ratio
business.industry
Liver Diseases
Insulin
Body Weight
Biochemistry (medical)
Fatty liver
Middle Aged
Thailand
medicine.disease
Body Height
Molecular Weight
Skinfold Thickness
Regression Analysis
Female
Metabolic syndrome
business
Biomarkers
Subjects
Details
- ISSN :
- 19457197 and 0021972X
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Endocrinology & Metabolism
- Accession number :
- edsair.doi.dedup.....e486c62975e54eec51fb6c9f71b3f015