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Effects of naloxone, metenkephalin, and morphine on phencyclidine-induced behavior in the rat
- Source :
- Psychopharmacology. 78(1)
- Publication Year :
- 1982
-
Abstract
- The effects of naloxone, metenkephalin, and morphine were tested on phencyclidine(PCP)-induced stereotyped behaviors, ataxia, and hyperactivity in the rat. Naloxone (8 mg/kg) significantly decreased stereotypy, ataxia, and hyperactivity across all PCP doses tested (2.0, 4.0, and 6.0 mg/kg). Metenkephalin (40 micrograms/kg) and morphine (5 and 10 mg/kg) increased ataxia at the 4.0 and 6.0 mg/kg PCP doses. Stereotypy was altered by the opiates in a dose-dependent manner; enhanced by metenkephalin (40 micrograms/kg) at 2.0 mg/kg and inhibited by metenkephalin (40 micrograms/kg) and morphine (10 mg/kg) at 4.0 and 6.0 mg/kg PCP. Locomotor activity was increased by morphine (5 mg/kg) at 2 mg/kg PCP. These results suggest an involvement of central opiate receptor mechanisms in the mediation of PCP-induced behaviors in the rat.
- Subjects :
- Male
Ataxia
Enkephalin
Enkephalin, Methionine
Phencyclidine
(+)-Naloxone
Pharmacology
Motor Activity
medicine
Animals
Humans
Behavior, Animal
Dose-Response Relationship, Drug
Morphine
Chemistry
Naloxone
Rats, Inbred F344
Rats
Stereotypy (non-human)
Dose–response relationship
Motor Skills
medicine.symptom
Opiate
Stereotyped Behavior
medicine.drug
Subjects
Details
- ISSN :
- 00333158
- Volume :
- 78
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Psychopharmacology
- Accession number :
- edsair.doi.dedup.....e4843fdef492189bec38f816ecd3e14c