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Mid-sagittal plane detection for advanced physiological measurements in brain scans
- Publication Year :
- 2019
- Publisher :
- IOP Publishing Ltd, 2019.
-
Abstract
- Objective The process of diagnosing many neurodegenerative diseases, such as Parkinson's and progressive supranuclear palsy, involves the study of brain magnetic resonance imaging (MRI) scans in order to identify and locate morphological markers that can highlight the health status of the subject. A fundamental step in the pre-processing and analysis of MRI scans is the identification of the mid-sagittal plane, which corresponds to the mid-brain and allows a coordinate reference system for the whole MRI scan set. Approach To improve the identification of the mid-sagittal plane we have developed an algorithm in Matlab® based on the k-means clustering function. The results have been compared with the evaluation of four experts who manually identified the mid-sagittal plane and whose performances have been combined with a cognitive decisional algorithm in order to define a gold standard. Main results The comparison provided a mean percentage error of 1.84%. To further refine the automatic procedure we trained a machine learning system using the results from the proposed algorithm and the gold standard. We tested this machine learning system and obtained results comparable to medical raters with a mean absolute error of 1.86 slices. Significance The system is promising and could be directly incorporated into broader diagnostic support systems.
- Subjects :
- Male
Physiology
Computer science
Biomedical Engineering
Biophysics
k-means algorithm
Neuroimaging
Spatial reference system
Physiology (medical)
medicine
mid-sagittal plane
Humans
magnetic resonance imaging
Cluster analysis
Settore MAT/07 - Fisica Matematica
Aged
Image segmentation
medicine.diagnostic_test
business.industry
k-means clustering
Brain
Magnetic resonance imaging
Pattern recognition
Gold standard (test)
Middle Aged
Reference Standards
Sagittal plane
medicine.anatomical_structure
machine learning
Databases as Topic
Female
Artificial intelligence
business
Algorithms
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....e47683fc283ac49f9e4377f3b6e9910d