Back to Search
Start Over
The Immunobiology of T Cell Therapies for Leukemias
- Source :
- Acta Haematologica. 96:189-213
- Publication Year :
- 1996
- Publisher :
- S. Karger AG, 1996.
-
Abstract
- Allogeneic bone marrow transplantation has revolutionized the treatment of chronic myelogenous leukemia, acute myeloid leukemia, and acute lymphocytic leukemia. Some of this success is due to the high doses of chemotherapy and radiotherapy allowable by rescuing fatal hematologic toxicity with the bone marrow allograft. However, it has become increasingly clear that an alloimmune antileukemic effect mediated by mature donor derived T cells, termed the graft-versus-leukemia reaction (GVL), makes a strong contribution to the efficacy of alloBMT. This has been dramatically illustrated by the complete remissions obtained in patients with relapsed leukemias after alloBMT following the infusion of donor mononuclear cells from their original marrow donors. In this review, after summarizing the clinical data in support of this effect, we discuss current paradigms of T cell mediated immunity and how they can be applied to explain the immunobiology of the GVL reaction.
- Subjects :
- Immunity, Cellular
Chemotherapy
Leukemia
business.industry
T-Lymphocytes
medicine.medical_treatment
T cell
Alloimmunity
Graft vs Host Disease
Myeloid leukemia
Hematology
General Medicine
medicine.disease
Major Histocompatibility Complex
Graft-versus-host disease
medicine.anatomical_structure
Acute lymphocytic leukemia
Immunology
medicine
Humans
Bone marrow
business
Bone Marrow Transplantation
Chronic myelogenous leukemia
Subjects
Details
- ISSN :
- 14219662 and 00015792
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- Acta Haematologica
- Accession number :
- edsair.doi.dedup.....e454c5184cf8441920e7742d036c7ac8