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Graft-versus-Host Disease after HLA-Matched Sibling Bone Marrow or Peripheral Blood Stem Cell Transplantation: Comparison of North American Caucasian and Japanese Populations
- Source :
- Biology of Blood and Marrow Transplantation. 22(4):744-751
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- The risk of acute graft-versus-host disease (GVHD) after HLA-matched sibling bone marrow transplantation (BMT) is lower in Japanese than in Caucasian patients. However, race may have differential effect on GVHD dependent on the graft source. North American Caucasian and Japanese patients receiving their first allogeneic BMT or peripheral blood stem cell transplantation from an HLA-matched sibling for leukemia were eligible. BMT was performed in 13% of the Caucasian patients and in 53% of the Japanese patients. On multivariate analysis, the interaction term between race and graft source was not significant in any of the models, indicating that graft source does not affect the impact of race on outcomes. The risk of grade III or IV acute GVHD was significantly lower in the Japanese patients compared with the Caucasian patients (hazard ratio [HR], 0.74; 95% confidence interval [CI], 0.57 to 0.96), which resulted in lower risk of nonrelapse mortality in the Japanese patients (HR, 0.69; 95% CI, 0.54 to 0.89). The risk of relapse was also lower in this group. The lower risks of nonrelapse mortality and relapse resulted in lower overall mortality rates among the Japanese patients. In conclusion, our data indicate that irrespective of graft source, the risk of severe acute GVHD is lower in Japanese patients, resulting in a lower risk of nonrelapse mortality.
- Subjects :
- Adult
Male
Risk
medicine.medical_specialty
Adolescent
Graft vs Host Disease
Lower risk
Severity of Illness Index
White People
Article
03 medical and health sciences
0302 clinical medicine
Asian People
Recurrence
Internal medicine
medicine
Humans
Transplantation, Homologous
Sibling
Survival analysis
Bone Marrow Transplantation
Peripheral Blood Stem Cell Transplantation
Transplantation
Leukemia
business.industry
Histocompatibility Testing
Siblings
Mortality rate
Hazard ratio
Hematology
Middle Aged
medicine.disease
Survival Analysis
Tissue Donors
Surgery
medicine.anatomical_structure
Graft-versus-host disease
surgical procedures, operative
030220 oncology & carcinogenesis
Acute Disease
Chronic Disease
Female
Bone marrow
business
030215 immunology
Subjects
Details
- ISSN :
- 10838791
- Volume :
- 22
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Biology of Blood and Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....e44cc4b4dca5ff90be005edaa7cefd01
- Full Text :
- https://doi.org/10.1016/j.bbmt.2015.12.027