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Predictors of social instability stress effects on social interaction and anxiety in adolescent male rats
- Source :
- Developmental psychobiology. 60(6)
- Publication Year :
- 2017
-
Abstract
- Adolescence is an important phase of development of social behaviors, which may be disrupted by the experience of stressors. We previously reported that exposure to social instability stress in adolescence (SS; postnatal day [PND] 30-45) in rats reduced social interactions with unfamiliar peers compared with non-stressed controls (CTL). In experiment 1, we replicated the effect of SS on social interaction and found that the pattern of neural activations based on Fos immunohistochemistry in brain regions during social interactions differed for SS and CTL rats. In experiment 2, we found that individual differences in novelty-seeking behavior on PND 30 and SS exposure were unique predictors of anxiety in the elevated plus maze on PND 46, and interacted to predict social interaction on PND 47; among high novelty-seeking rats, SS and CTL rats do not differ, whereas among low-novelty seeking rats, SS rats engaged in less social interaction than did CTL rats. Thus, high novelty-seeking may be a resilience factor against the effects of social stressors in adolescence.
- Subjects :
- Male
Elevated plus maze
medicine.medical_specialty
Anxiety
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Developmental Neuroscience
Internal medicine
Developmental and Educational Psychology
Limbic System
Medicine
Animals
0501 psychology and cognitive sciences
Interpersonal Relations
Rats, Long-Evans
050102 behavioral science & comparative psychology
Social stress
Behavior, Animal
business.industry
05 social sciences
Stressor
Novelty seeking
Age Factors
Social relation
Rats
CTL
Endocrinology
Social Isolation
Exploratory Behavior
medicine.symptom
business
030217 neurology & neurosurgery
Stress, Psychological
Developmental Biology
Social behavior
Subjects
Details
- ISSN :
- 10982302
- Volume :
- 60
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Developmental psychobiology
- Accession number :
- edsair.doi.dedup.....e444f69b85a4eaab4a04a75baf2b170f