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Timing Is Everything: Coordinated Control of Host Shutoff by Influenza A Virus NS1 and PA-X Proteins
- Source :
- Journal of Virology. 89:6528-6531
- Publication Year :
- 2015
- Publisher :
- American Society for Microbiology, 2015.
-
Abstract
- Like all viruses, influenza viruses (IAVs) use host translation machinery to decode viral mRNAs. IAVs ensure efficient translation of viral mRNAs through host shutoff, a process whereby viral proteins limit the accumulation of host proteins through subversion of their biogenesis. Despite its small genome, the virus deploys multiple host shutoff mechanisms at different stages of infection, thereby ensuring successful replication while limiting the communication of host antiviral responses. In this Gem, we review recent data on IAV host shutoff proteins, frame the outstanding questions in the field, and propose a temporally coordinated model of IAV host shutoff.
- Subjects :
- Host (biology)
viruses
Immunology
Translation (biology)
Viral Nonstructural Proteins
biochemical phenomena, metabolism, and nutrition
Biology
Virus Replication
medicine.disease_cause
Microbiology
Virology
Genome
Virus
Time
Repressor Proteins
Viral envelope
Viral replication
Influenza A virus
Insect Science
Host-Pathogen Interactions
medicine
Gems
Biogenesis
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 89
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....e437c1670a9f731410d157c3d73aac70