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Corticotropin-releasing hormone mediates α-melanocyte-stimulating hormone-induced anorexigenic action in goldfish
- Source :
- Peptides. 29:1930-1936
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- alpha-Melanocyte-stimulating hormone (alpha-MSH) and corticotropin-releasing hormone (CRH) both suppress food intake, and the alpha-MSH- or CRH-signaling pathway has possible potency to mediate anorexigenic actions induced by most other neuropeptides in goldfish. Therefore, using specific receptor antagonists, we examined whether the anorexigenic actions of alpha-MSH and CRH mutually interact. The inhibitory effect of ICV injection of the alpha-MSH agonist, melanotan II (MT II), on food intake was abolished by treatment with a CRH 1/2 receptor antagonist, alpha-helical CRH((9-41)), whereas the anorexigenic action of ICV-injected CRH was not affected by treatment with a melanocortin 4 receptor antagonist, HS024. This led us to investigate whether alpha-MSH-containing neurons in the goldfish brain have direct inputs to CRH-containing neurons, using confocal laser scanning microscopy. alpha-MSH- and CRH-like immunoreactivities were distributed throughout the brain, especially in the diencephalon. alpha-MSH-containing nerve fibers or endings lay in close apposition to CRH-containing neurons in a region of the hypothalamus, the nucleus posterioris periventricularis (NPPv). These results indicate that, in goldfish, alpha-MSH-induced anorexigenic action is mediated by the CRH-signaling pathway, and that CRH plays a crucial role in the regulation of feeding behavior as an integrated anorexigenic neuropeptide in this species.
- Subjects :
- Male
endocrine system
medicine.medical_specialty
Melanocyte-stimulating hormone
Corticotropin-Releasing Hormone
Physiology
medicine.drug_class
Hypothalamus
Fluorescent Antibody Technique
Neuropeptide
Peptides, Cyclic
Biochemistry
Eating
Cellular and Molecular Neuroscience
Corticotropin-releasing hormone
Endocrinology
Goldfish
Internal medicine
medicine
Animals
Melanocyte-Stimulating Hormones
Receptor
Injections, Intraventricular
integumentary system
Chemistry
Melanotan II
Receptor antagonist
Peptide Fragments
Melanocortin 4 receptor
nervous system
alpha-MSH
Female
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 01969781
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Peptides
- Accession number :
- edsair.doi.dedup.....e42818fe7be564ab0a59eaca5066d271