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Further evaluation of autoreactive T cells in hydatid patients
Further evaluation of autoreactive T cells in hydatid patients
- Source :
- Immunology letters. 40(1)
- Publication Year :
- 1994
-
Abstract
- We evaluated the peripheral autoreactive response in patients with Echinococcus granulosus who showed a negative humoral response as compared to seropositive patients and healthy controls. For this purpose, a limiting dilution analysis (LDA) of autologous mixed lymphocyte cultures was established to both estimate frequency of autoreactive T cells and, by analysing the shape of the curves, to clarify the mechanisms that underlie the autoreactive response. Different LDA curves were observed between healthy controls and patients, suggesting that different cell interactions are involved in the two populations. More interestingly, all hydatid patients, independent of their humoral response, showed a higher number of autoreactive T cells than controls. Precisely, subjects with a negative humoral response showed a range of values for autoreactive T cells exactly between the value ranges observed in seropositive and normal subjects. The present data also show that the increase of autoreactive T cells in hydatid patients correlates with the production of specific antibodies.
- Subjects :
- Adult
Male
Echinococcosis, Hepatic
Echinococcosis, Pulmonary
Lymphocyte
T-Lymphocytes
Immunology
Cell
medicine.disease_cause
Lymphocyte Activation
Autoimmunity
Pathogenesis
Immune system
parasitic diseases
medicine
Immunology and Allergy
Humans
Echinococcus granulosus
Cells, Cultured
Aged
Aged, 80 and over
biology
T lymphocyte
Middle Aged
biology.organism_classification
medicine.anatomical_structure
Humoral immunity
Female
Lymphocyte Culture Test, Mixed
Subjects
Details
- ISSN :
- 01652478
- Volume :
- 40
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Immunology letters
- Accession number :
- edsair.doi.dedup.....e426cbe9329bbddaa67bfb385e52a1d7