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WITHDRAWN: Could implant position influence the peri-implant parameters in edentulous mandibles of diabetics rehabilitated with overdentures? A split-mouth randomized study
- Source :
- International Journal of Oral and Maxillofacial Surgery.
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- This randomized controlled trial assessed the impact of crestal level position of implants installed in type 2 diabetes mellitus (T2DM) patients rehabilitated with overdentures. Twenty-two mandibular edentulous T2DM patients were submitted to implant placement for retention of an overdenture. By means of a split-mouth design, two implants were installed: one at supracrestal level (SL) and one at crestal level (CL). Clinical, immunoenzymatic and tomographic analyses were performed at prosthesis placement (baseline) and after 6, 12 and 24 months following implant loading. Increased peri-implant probing depths were detected in CL implants when compared with SL implants at all time-points (baseline P=0.047; 6 months P=0.014; 12 months P=0.027; 24 months P=0.036). Indeed, augmented clinical attachment levels were also detected in CL implants when compared with SL implants at all time-points (baseline P=003; 6 months P=0.045; 12 months P=0.029; 24 months P=0.026). CL implants demonstrated increased amounts of interleukin-6 (IL-6) at 6 months (P=0.043) and higher IL-17 (P=0.021), IL-21 (P=0.034) and tumour necrosis factor alpha (TNF-α) concentrations (P=0.030) at 24 months in comparison with SL implants. CL group revealed enhanced bone loss from baseline to 6 (P=0.032), 12 (P=0.043) and 24 months (P=0.028) when compared with SL. In conclusion, this study showed that implants placed supracrestally in T2DM patients rehabilitated with overdentures demonstrated lower bone loss and better clinical parameters with beneficial modulation of peri-implant immunoinflammatory biomarkers when compared with implants positioned at crestal level.
- Subjects :
- business.industry
medicine.medical_treatment
Dental prosthesis
Peri
Dentistry
030206 dentistry
Tumour necrosis factor alpha
Prosthesis
law.invention
Implant placement
03 medical and health sciences
0302 clinical medicine
Otorhinolaryngology
Randomized controlled trial
law
030220 oncology & carcinogenesis
medicine
Surgery
Implant loading
Implant
Oral Surgery
business
Subjects
Details
- ISSN :
- 09015027
- Database :
- OpenAIRE
- Journal :
- International Journal of Oral and Maxillofacial Surgery
- Accession number :
- edsair.doi.dedup.....e41092643cbb813941ff8e1abc0163be