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Patients' education level and treatment modality for prostate cancer in the Finnish Randomized Study of Screening for Prostate Cancer
- Source :
- European Journal of Cancer. 130:204-210
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Background In prostate cancer (PCa), lower education level is associated with less screening, more advanced stage at diagnosis and worse survival. The aim of this study was to estimate the association between education level and treatment modality and subsequently survival. Methods The 9255 men diagnosed with PCa in the Finnish Randomized Study of Screening for Prostate Cancer were included. Cancer stage, comorbidity, education level and primary treatment modality were extracted from the patient records, the Finnish Cancer Registry, Statistics Finland and the National Institute of Health and Welfare, and these covariates were used in logistic regression (treatment selection) and Cox regression (survival analysis). Results In high-risk cancers, men with tertiary education were more likely to be treated with radical prostatectomy (odds ratio [OR] = 1.76; 95% confidence interval [CI] = 1.27–2.44) than men with primary education. Men with secondary (OR = 0.57; 95% CI = 0.38–0.84) or tertiary (OR = 0.42; 95% CI = 0.29–0.60) education were managed less frequently with mere hormonal therapy. In locally advanced cases, tertiary education was associated with more curatively aimed therapies and less hormonal therapy (OR for radical prostatectomy = 2.34; 95% CI = 1.49–3.66; OR for radiotherapy = 1.42; 95% CI = 1.09–1.85; OR for hormonal therapy = 0.45; 95% CI = 0.33–0.60). The hazard ratio for PCa death was lower in men with secondary (0.81; 95% CI = 0.69–0.95) and tertiary (0.75; 95% CI = 0.65–0.87) education than in the patients with primary education. Conclusions When controlled for the cancer risk group, comorbidity and patient's age, low education level is independently associated with less curatively aimed treatment in men with high-risk or locally advanced PCa and subsequently worse prognosis.
- Subjects :
- Male
0301 basic medicine
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Patient Education as Topic
Internal medicine
medicine
Humans
Early Detection of Cancer
Finland
Aged
Proportional hazards model
business.industry
Prostatectomy
Hazard ratio
Prostatic Neoplasms
Odds ratio
medicine.disease
Comorbidity
3. Good health
Cancer registry
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Hormonal therapy
business
Subjects
Details
- ISSN :
- 09598049
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- European Journal of Cancer
- Accession number :
- edsair.doi.dedup.....e40db99e03a5c2f76aa554347aa9a81a