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Preclinical In Vitro Activity of QR-435 Against Influenza A Virus as a Virucide and in Paper Masks for Prevention of Viral Transmission
- Source :
- American Journal of Therapeutics. 14:455-461
- Publication Year :
- 2007
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2007.
-
Abstract
- Prophylaxis against influenza is difficult, and current approaches against pandemics may be ineffective because of shortages of the two proven classes of antivirals in the face of a large-scale infection. Herbal/natural products may represent an effective alternative to conventional attempts to protect against infection by avian influenza virus. QR-435, an all-natural compound of green tea extract and other agents, has been developed to provide protection against a wide range of viral infections. The antiviral activities of several QR-435 preparations as well as QR-435 (1) green tea extract were tested against A/Sydney/5/97 and A/Panama-Resvir 17 strains of avian influenza virus H3N2 by means of an assay based on Madin-Darby canine kidney cells. Toxic effects of QR-435 formulations on these cells were also evaluated as were the virucidal properties of a commercially available mask impregnated with QR-435. The efficacy of a QR-435/mask combination was compared with that of the QR control/mask combination, an untreated mask, and no mask. QR-435 had significant in vitro activity against H3N2 at concentrations that were not associated with significant cellular toxic effects. The antiviral activity of QR-435 (1) was similar to that of QR-435. Masks impregnated with QR-435 were highly effective in blocking the passage of live H3N2 virus. These preclinical results warrant further evaluation of the prophylactic use of QR-435 against viral infection in humans.
- Subjects :
- Paper
Drug
media_common.quotation_subject
Drug Evaluation, Preclinical
Viral transmission
Green tea extract
Kidney
medicine.disease_cause
Antiviral Agents
Virus
Microbiology
Dogs
Virucide
Influenza, Human
Toxicity Tests
Pandemic
Influenza A virus
Animals
Humans
Medicine
Pharmacology (medical)
media_common
Pharmacology
Infection Control
Dose-Response Relationship, Drug
Tea
Plant Extracts
business.industry
Influenza A Virus, H3N2 Subtype
Masks
General Medicine
Combined Modality Therapy
Virology
In vitro
business
Subjects
Details
- ISSN :
- 10752765
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- American Journal of Therapeutics
- Accession number :
- edsair.doi.dedup.....e3fc3c6742b92522a74f9095d6be015e