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Long-term anticoagulant therapy in coronary atherosclerosis

Authors :
Robert L. Page
Joseph F. Borg
E. Sterling Nichol
William L. Mullins
John J. Boehrer
Thornton Scott
John N. Keyes
George C. Griffith
Edward Massie
Thomas J. Coogan
Source :
American heart journal. 55(1)
Publication Year :
1958

Abstract

We have presented a pooled clinical investigation in 1,091 patients with coronary atheroslcerosis treated with long-term anticoagulants for 3 to 100 months, for a total of 24,454 months. The average duration of therapy was 22.4 months. Four and four-tenths per cent developed non-fatal thromboembolism, and 131 patients, or 12.0 per cent, died on the regimen, mostly from cardiac disease. Three hundred nineteen patients, or 29.2 per cent, abandoned the regimen; an average 18.4 months' follow-up of these showed that 28.2 per cent died within 4 years, chiefly with cardiac disease. These 319 patients serve as “controls”. Six hundred sixty-nine patients, or 61.3 per cent, continued the regimen an average of 27.6 months of therapy. Four hundred seventeen patients not given anticoagulants were used as additional “controls” and were followed by 5 of the authors for 3 to 120 months, averaging 38.1 months. Of these, 37.4 per cent died, the majority from cardiovascular disease.

Details

ISSN :
00028703
Volume :
55
Issue :
1
Database :
OpenAIRE
Journal :
American heart journal
Accession number :
edsair.doi.dedup.....e3fb07ed0f72460c213e9609d9480a6a