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Long-term anticoagulant therapy in coronary atherosclerosis
- Source :
- American heart journal. 55(1)
- Publication Year :
- 1958
-
Abstract
- We have presented a pooled clinical investigation in 1,091 patients with coronary atheroslcerosis treated with long-term anticoagulants for 3 to 100 months, for a total of 24,454 months. The average duration of therapy was 22.4 months. Four and four-tenths per cent developed non-fatal thromboembolism, and 131 patients, or 12.0 per cent, died on the regimen, mostly from cardiac disease. Three hundred nineteen patients, or 29.2 per cent, abandoned the regimen; an average 18.4 months' follow-up of these showed that 28.2 per cent died within 4 years, chiefly with cardiac disease. These 319 patients serve as “controls”. Six hundred sixty-nine patients, or 61.3 per cent, continued the regimen an average of 27.6 months of therapy. Four hundred seventeen patients not given anticoagulants were used as additional “controls” and were followed by 5 of the authors for 3 to 120 months, averaging 38.1 months. Of these, 37.4 per cent died, the majority from cardiovascular disease.
- Subjects :
- medicine.medical_specialty
Average duration
Cardiotonic Agents
business.industry
Anticoagulants
Coronary Disease
Disease
Coronary Artery Disease
Surgery
Regimen
Anticoagulant therapy
Clinical investigation
medicine
Humans
Cardiology and Cardiovascular Medicine
business
Diuretics
Anti-Arrhythmia Agents
Coronary atherosclerosis
Subjects
Details
- ISSN :
- 00028703
- Volume :
- 55
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- American heart journal
- Accession number :
- edsair.doi.dedup.....e3fb07ed0f72460c213e9609d9480a6a