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Relationship of circulating tumor cells and Epstein–Barr virus DNA to progression‐free survival and overall survival in metastatic nasopharyngeal carcinoma patients
- Source :
- International Journal of Cancer. 145:2873-2883
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- We analyzed the number of circulating tumor cells (CTCs) and Epstein-Barr virus DNA (EBV DNA) for diagnosis, monitoring and prognosis of patients with metastatic nasopharyngeal carcinoma (mNPC). The levels of CTCs and EBV DNA were measured at baseline and after first-line chemotherapy in 148 mNPC patients prospectively enrolled between December 2014 and August 2016. We also collected 122 non-mNPC cases within the same time frame for examining CTCs and EBV DNA at baseline. In 270 NPC patients, we observed improved specificity (86.0% vs. 41.0%) and inferior sensitivity (42.3% vs. 81.3%) of CTCs as compared to EBV DNA for diagnosis of distant metastasis. mNPC patients were stratified into unfavorable and favorable prognostic groups, respectively, based on CTC of 12 at baseline and 1 after first-line chemotherapy and EBV DNA of 10,000 at baseline and 4,000 after first-line chemotherapy. Conversion of baseline unfavorable CTCs and EBV DNA to favorable after first-line chemotherapy was associated with significantly longer progression-free survival (PFS) and overall survival (OS) compared to patients with unfavorable CTCs and EBV DNA at both time points. Among patients with a complete/partial response as per imaging evaluation, favorable CTCs and EBV DNA levels after first-line chemotherapy were associated with significantly longer PFS and OS. In conclusion, our data demonstrated the number of CTCs and EBV DNA before, after and during first-line chemotherapy were strong predictive markers for mNPC patients. When utilized in conjunction with imaging studies, CTCs and EBV DNA could provide additional prognostic information.
- Subjects :
- Adult
Male
Oncology
Herpesvirus 4, Human
Cancer Research
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Kaplan-Meier Estimate
Virus
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Circulating tumor cell
Predictive Value of Tests
hemic and lymphatic diseases
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
medicine
Overall survival
Humans
Prospective Studies
Progression-free survival
Aged
Chemotherapy
Nasopharyngeal Carcinoma
business.industry
Epstein-Barr virus DNA
Nasopharyngeal Neoplasms
Middle Aged
Neoplastic Cells, Circulating
Prognosis
medicine.disease
Progression-Free Survival
Nasopharyngeal carcinoma
chemistry
030220 oncology & carcinogenesis
DNA, Viral
Female
business
DNA
Subjects
Details
- ISSN :
- 10970215 and 00207136
- Volume :
- 145
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer
- Accession number :
- edsair.doi.dedup.....e3f2c6232f9cacaabdf6b822dda79291
- Full Text :
- https://doi.org/10.1002/ijc.32380