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Photoacoustic imaging in the second near-infrared window: a review
- Source :
- Journal of Biomedical Optics
- Publication Year :
- 2019
- Publisher :
- Society of Photo-Optical Instrumentation Engineers, 2019.
-
Abstract
- Photoacoustic (PA) imaging is an emerging medical imaging modality that combines optical excitation and ultrasound detection. Because ultrasound scatters much less than light in biological tissues, PA generates high-resolution images at centimeters depth. In recent years, wavelengths in the second near-infrared (NIR-II) window (1000 to 1700 nm) have been increasingly explored due to its potential for preclinical and clinical applications. In contrast to the conventional PA imaging in the visible (400 to 700 nm) and the first NIR-I (700 to 1000 nm) window, PA imaging in the NIR-II window offers numerous advantages, including high spatial resolution, deeper penetration depth, reduced optical absorption, and tissue scattering. Moreover, the second window allows a fivefold higher light excitation energy density compared to the visible window for enhancing the imaging depth significantly. We highlight the importance of the second window for PA imaging and discuss the various NIR-II PA imaging systems and contrast agents with strong absorption in the NIR-II spectral region. Numerous applications of NIR-II PA imaging, including whole-body animal imaging and human imaging, are also discussed. NMRC (Natl Medical Research Council, S’pore) Published version
- Subjects :
- Paper
Materials science
Infrared Rays
Biomedical Engineering
Contrast Media
01 natural sciences
010309 optics
Biomaterials
Photoacoustic Techniques
Mice
Optics
Dogs
small animal imaging
0103 physical sciences
Medical imaging
Animals
Humans
contrast agents
Whole Body Imaging
Photoacoustic Imaging
Penetration depth
Absorption (electromagnetic radiation)
Review Papers
deep-tissue imaging
business.industry
Phantoms, Imaging
Ultrasound
Near-infrared spectroscopy
Optical Imaging
Chemical engineering [Engineering]
Window (computing)
Equipment Design
second near-infrared window
Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Rats
Second Near Infra-red Window
Wavelength
Liver
photoacoustic imaging
business
Preclinical imaging
Subjects
Details
- Language :
- English
- ISSN :
- 15602281 and 10833668
- Volume :
- 24
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Optics
- Accession number :
- edsair.doi.dedup.....e3e0c8f96302e20a5a4333f29e384bff