Nanocellulose/palygorskite biocomposite membranes for controlled release of metronidazole

Made available in DSpace on 2022-04-29T08:32:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-10-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) The incorporation of drugs in nanocomposites can be considered a potential strategy for controlled drug release. In this study, a nanocomposite based on bacterial cellulose and the palygorskite clay (BC/PLG) was produced and loaded with metronidazole (MTZ). The samples were characterized using X-ray diffraction (XRD) Spectroscopy, thermal analysis (TG/DTG) and Scanning Electron Microscopy (SEM). The barrier properties were determined to water vapor permeability (WVP). Adsorption tests with PLG were performed using MTZ and drug release profile of the membranes was investigated. The results indicated that PLG increased the crystallinity of the nanocomposites, and greater thermal stability when PLG concentration was 15.0% (BC/PLG15) was observed. WVP of the samples also varied, according to the clay content. Adsorption equilibrium was achieved from 400 mg/L of the PLG and a plateau in the MTZ release rates from BC/PLG was observed after 30 min. Therefore, the results of this study show the potential of these nanocomposite membranes as a platform for controlled drug release. São Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Drugs and Medicines, Rodovia Araraquara-Jaú, km 1, - Campus Ville Research Center on Biotechnology Uniara LIMAV Interdisciplinary Laboratory for Advanced Materials Federal University of Piaui, Campus Universitário Ministro Petrônio Portella Center for Mineral Technology, Cidade Universitária São Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Drugs and Medicines, Rodovia Araraquara-Jaú, km 1, - Campus Ville FAPESP: 2013/07793-6 FAPESP: 2018/25512-8 FAPESP: 2019/19817-3 CNPq: 407822/2018-6