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Natural killer cells, gamma delta T cells and classical monocytes are associated with systolic blood pressure in the multi-ethnic study of atherosclerosis (MESA)
- Source :
- BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-9 (2021), BMC Cardiovascular Disorders
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Background Hypertension is a major source of cardiovascular morbidity and mortality. Recent evidence from mouse models, genetic, and cross-sectional human studies suggest increased proportions of selected immune cell subsets may be associated with levels of systolic blood pressure (SBP). Methods We assayed immune cells from cryopreserved samples collected at the baseline examination (2000–2002) from 1195 participants from the multi-ethnic study of atherosclerosis (MESA). We used linear mixed models, with adjustment for age, sex, race/ethnicity, smoking, exercise, body mass index, education, diabetes, and cytomegalovirus titers, to estimate the associations between 30 immune cell subsets (4 of which were a priori hypotheses) and repeated measures of SBP (baseline and up to four follow-up measures) over 10 years. The analysis provides estimates of the association with blood pressure level. Results The mean age of the MESA participants at baseline was 64 ± 10 years and 53% were male. A one standard deviation (1-SD) increment in the proportion of γδ T cells was associated with 2.40 mmHg [95% confidence interval (CI) 1.34–3.42] higher average systolic blood pressure; and for natural killer cells, a 1-SD increment was associated with 1.88 mmHg (95% CI 0.82–2.94) higher average level of systolic blood pressure. A 1-SD increment in classical monocytes (CD14++CD16−) was associated with 2.01 mmHG (95% CI 0.79–3.24) lower average systolic blood pressure. There were no associations of CD4+ T helper cell subsets with average systolic blood pressure. Conclusion These findings suggest that the innate immune system plays a role in levels of SBP whereas there were no associations with adaptive immune cells.
- Subjects :
- Male
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
CD14
Adaptive immunity
Blood Pressure
030204 cardiovascular system & hematology
Monocytes
Immunophenotyping
03 medical and health sciences
0302 clinical medicine
Immune system
Internal medicine
Diabetes mellitus
medicine
Humans
Lymphocytes
Intraepithelial Lymphocytes
Aged
030304 developmental biology
Aged, 80 and over
Innate immunity
0303 health sciences
business.industry
T helper cell
Middle Aged
Prognosis
medicine.disease
Acquired immune system
Cryopreserved cells
Immunity, Innate
United States
Confidence interval
Killer Cells, Natural
Phenotype
Blood pressure
medicine.anatomical_structure
Longitudinal cohort study
lcsh:RC666-701
Case-Control Studies
Hypertension
Systolic blood pressure
Cardiology
Female
Γδ T cells
Cardiology and Cardiovascular Medicine
business
Body mass index
Research Article
Subjects
Details
- ISSN :
- 14712261
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- BMC Cardiovascular Disorders
- Accession number :
- edsair.doi.dedup.....e3cc2ad6003e302165ab33fa2797522d