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Essential roles of Gab1 tyrosine phosphorylation in growth factor-mediated signaling and angiogenesis
- Source :
- International Journal of Cardiology. 181:180-184
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Growth factors and their downstream receptor tyrosine kinases (RTKs) mediate a number of biological processes controlling cell function. Adaptor (docking) proteins, which consist exclusively of domains and motifs that mediate molecular interactions, link receptor activation to downstream effectors. Recent studies have revealed that Grb2-associated-binders (Gab) family members (including Gab1, Gab2, and Gab3), when phosphorylated on tyrosine residues, provide binding sites for multiple effector proteins, such as Src homology-2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) and phosphatidylinositol 3-kinase (PI3K) regulatory subunit p85, thereby playing important roles in transducing RTKs-mediated signals into pathways with diversified biological functions. Here, we provide an up-to-date overview on the domain structure and biological functions of Gab1, the most intensively studied Gab family protein, in growth factor signaling and biological functions, with a special focus on angiogenesis.
- Subjects :
- Neovascularization, Physiologic
Protein tyrosine phosphatase
SH2 domain
Article
Receptor tyrosine kinase
SH3 domain
chemistry.chemical_compound
Animals
Humans
Medicine
Phosphorylation
Adaptor Proteins, Signal Transducing
biology
business.industry
Tyrosine phosphorylation
Protein-Tyrosine Kinases
Cell biology
chemistry
ROR1
biology.protein
Cancer research
Intercellular Signaling Peptides and Proteins
GRB2
Cardiology and Cardiovascular Medicine
business
Signal Transduction
Proto-oncogene tyrosine-protein kinase Src
Subjects
Details
- ISSN :
- 01675273
- Volume :
- 181
- Database :
- OpenAIRE
- Journal :
- International Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....e3be1a3afff7d4f24859bb3c26e88b7d