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Adhesion molecules: a new target for immunoliposome-mediated drug delivery
- Source :
- FEBS Letters. (2):140-144
- Publisher :
- Published by Elsevier B.V.
-
Abstract
- The anti-ICAM-1 monoclonal antibody F10.2 was conjugated to liposomes to target to cells expressing the cell adhesion molecule ICAM-1. We demonstrate that F10.2 immunoliposomes bind to human bronchial epithelial cells (BEAS-2B) and human umbilical vein endothelial cells (HUVEC) in a specific, dose- and time-dependent manner. It appears that the degree of ICAM-1 expression is the limiting factor in the degree of immunoliposome binding to the cells. These results are a first step in the strategy for specific drug delivery to target sites characterised by increased expression of adhesion molecules.
- Subjects :
- PL
Umbilical Veins
BSA
Biochemistry
Umbilical vein
Epithelium
chemistry.chemical_compound
Drug Delivery Systems
HUVEC
Structural Biology
HBS
Immunoliposome
PBS
IFN-γ
VCAM-1
ICAM-1
Cell adhesion molecule
Chemistry
EDTA
Antibodies, Monoclonal
FCS
Intercellular Adhesion Molecule-1
Cell biology
Drug delivery
SATA
Monoclonal antibody
MFI
medicine.drug_class
Biophysics
Bronchi
MPB-PE
Cell Line
DMF
Genetics
medicine
Humans
Endothelium
Molecular Biology
mAb
PHEPC
Cell Biology
Molecular biology
GamFITC
TNF-α
Liposomes
EPG
Endothelium, Vascular
CHOL
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....e39816d7bcba597644b889bc53baa680
- Full Text :
- https://doi.org/10.1016/0014-5793(94)01350-A