Back to Search Start Over

Adhesion molecules: a new target for immunoliposome-mediated drug delivery

Authors :
M.C. van den Tweel
Gert Storm
Paul A.J. Henricks
L. van Bloois
Daan J.A. Crommelin
A.C. Bloem
Frans P. Nijkamp
P.G.M. Bloemen
Source :
FEBS Letters. (2):140-144
Publisher :
Published by Elsevier B.V.

Abstract

The anti-ICAM-1 monoclonal antibody F10.2 was conjugated to liposomes to target to cells expressing the cell adhesion molecule ICAM-1. We demonstrate that F10.2 immunoliposomes bind to human bronchial epithelial cells (BEAS-2B) and human umbilical vein endothelial cells (HUVEC) in a specific, dose- and time-dependent manner. It appears that the degree of ICAM-1 expression is the limiting factor in the degree of immunoliposome binding to the cells. These results are a first step in the strategy for specific drug delivery to target sites characterised by increased expression of adhesion molecules.

Details

Language :
English
ISSN :
00145793
Issue :
2
Database :
OpenAIRE
Journal :
FEBS Letters
Accession number :
edsair.doi.dedup.....e39816d7bcba597644b889bc53baa680
Full Text :
https://doi.org/10.1016/0014-5793(94)01350-A