Back to Search
Start Over
Identification and Functional Characterization of Brainstem Cannabinoid CB 2 Receptors
- Source :
- Science. 310:329-332
- Publication Year :
- 2005
- Publisher :
- American Association for the Advancement of Science (AAAS), 2005.
-
Abstract
- The presence and function of CB 2 receptors in central nervous system (CNS) neurons are controversial. We report the expression of CB 2 receptor messenger RNA and protein localization on brainstem neurons. These functional CB 2 receptors in the brainstem were activated by a CB 2 receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB 1 receptors. CB 2 receptors represent an alternative site of action of endocannabinoids that opens the possibility of nonpsychotropic therapeutic interventions using enhanced endocannabinoid levels in localized brain areas.
- Subjects :
- medicine.medical_specialty
Cannabinoid receptor
Polyunsaturated Alkamides
Vomiting
Blotting, Western
Class C GPCR
Arachidonic Acids
Immune receptor
Biology
Receptor, Cannabinoid, CB2
Mice
Cerebellum
Internal medicine
Cannabinoid Receptor Modulators
medicine
Animals
RNA, Messenger
Receptor
Long-term depression
Cerebral Cortex
Multidisciplinary
Cannabinoids
Reverse Transcriptase Polymerase Chain Reaction
Ferrets
Immunohistochemistry
Endocannabinoid system
Rats
Endocrinology
Metabotropic receptor
GPR18
Neuroscience
Brain Stem
Endocannabinoids
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 310
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....e3907df2c71d9f0fefb3ea22003ad243