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Differentiation Among Metastatic Brain Tumors, Radiation Necroses, and Brain Abscesses Using Proton Magnetic Resonance Spectroscopy
- Source :
- Kaohsiung Journal of Medical Sciences, Vol 20, Iss 9, Pp 437-442 (2004)
- Publication Year :
- 2004
- Publisher :
- Wiley, 2004.
-
Abstract
- Magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (MRS) were evaluated for differentiating metastatic brain tumors, radiation necroses, and brain abscesses. Twelve histologically verified lesions in 12 patients were studied using preoperative MRI and proton MRS. The signal intensities of four major metabolites, N-acetyl aspartate (NAA), choline-containing compounds (Cho), creatine and phosphocreatine (Cr), and lactate (Lac), were observed over the region of interest. Metastatic brain tumors showed a decrease in NAA/Cr and an increase in Cho/Cr ratios. Radiation necroses showed a decrease in NAA/Cr and no change in Cho/Cr ratios. Brain abscesses showed an increase in Lac/Cr ratio. Correlation with histopathologic findings showed that a high Cho signal was suggestive of a metastatic brain tumor. Lac signals were observed in brain abscesses, presumably reflecting the anerobic glycolysis of living cells. Although more cases and studies are necessary, metabolic information provided by proton MRS combined with MRI is useful for differentiating among metastatic brain tumors, radiation necroses, and brain abscesses.
- Subjects :
- Adult
Male
Necrosis
Creatine
Sensitivity and Specificity
Phosphocreatine
Diagnosis, Differential
chemistry.chemical_compound
medicine
Humans
magnetic resonance imaging
metastatic brain tumor
Radiation Injuries
Brain abscess
Aged
Aged, 80 and over
Medicine(all)
lcsh:R5-920
medicine.diagnostic_test
Brain Neoplasms
business.industry
Brain
radiation necrosis
Magnetic resonance imaging
General Medicine
Middle Aged
medicine.disease
magnetic resonance spectroscopy
Proton magnetic resonance
brain abscess
Metastatic brain tumor
chemistry
Female
Protons
medicine.symptom
Differential diagnosis
lcsh:Medicine (General)
Nuclear medicine
business
Subjects
Details
- ISSN :
- 1607551X
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- The Kaohsiung Journal of Medical Sciences
- Accession number :
- edsair.doi.dedup.....e38cdc027a1e5ccfd8fd53eafbd29887