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Targeting ferritin receptors for the selective delivery of imaging and therapeutic agents to breast cancer cells
Targeting ferritin receptors for the selective delivery of imaging and therapeutic agents to breast cancer cells
- Source :
- Nanoscale. 7:6527-6533
- Publication Year :
- 2015
- Publisher :
- Royal Society of Chemistry (RSC), 2015.
-
Abstract
- In this work the selective uptake of native horse spleen ferritin and apoferritin loaded with MRI contrast agents has been assessed in human breast cancer cells (MCF-7 and MDA-MB-231). The higher expression of L-ferritin receptors (SCARA5) led to an enhanced uptake in MCF-7 as shown in T2 and T1 weighted MR images, respectively. The high efficiency of ferritin internalization in MCF-7 has been exploited for the simultaneous delivery of curcumin, a natural therapeutic molecule endowed with antineoplastic and anti-inflammatory action, and the MRI contrast agent Gd-HPDO3A. This theranostic system is able to treat selectively breast cancer cells over-expressing ferritin receptors. By entrapping in apoferritin both Gd-HPDO3A and curcumin, it was possible to deliver a therapeutic dose of 167 μg ml−1 (as calculated by MRI) of this natural drug to MCF-7 cells, thus obtaining a significant reduction of cell proliferation. Fil: Geninatti Crich, S.. Universitã â Di Torino; Italia Fil: Cadenazzi, M.. Universitã â Di Torino; Italia Fil: Lanzardo, S.. Universitã â Di Torino; Italia Fil: Conti, L.. Universitã â Di Torino; Italia Fil: Ruiu, R.. Universitã â Di Torino; Italia Fil: Alberti, D.. Universitã â Di Torino; Italia Fil: Cavallo, F.. Universitã â Di Torino; Italia Fil: Cutrin, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Università  Di Torino; Italia Fil: Aime, S.. Universitã â Di Torino; Italia
- Subjects :
- Curcumin
Theranostic Nanomedicine
MRI contrast agent
Anti-Inflammatory Agents
Contrast Media
Antineoplastic Agents
Breast Neoplasms
Receptors, Cell Surface
INGENIERÍAS Y TECNOLOGÍAS
chemistry.chemical_compound
Therapeutic index
BREAST CANCER
Cell Line, Tumor
Iron-Binding Proteins
Animals
Humans
THERANOSTIC
General Materials Science
Otras Nanotecnología
Horses
skin and connective tissue diseases
Receptor
Cell Proliferation
Nanotecnología
Drug Carriers
biology
Temperature
Scavenger Receptors, Class A
Magnetic Resonance Imaging
Ferritin
Agar
chemistry
Cell culture
Apoferritins
Ferritins
Immunology
Cancer cell
MCF-7 Cells
Cancer research
biology.protein
Female
Materials Science (all)
FERRITIN
Spleen
MRI
Subjects
Details
- ISSN :
- 20403372 and 20403364
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Nanoscale
- Accession number :
- edsair.doi.dedup.....e37f2162a294df157802bc657e6f7b68
- Full Text :
- https://doi.org/10.1039/c5nr00352k