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Continuous intravenous sodium ferric gluconate improves efficacy in the maintenance phase of EPOrHu administration in hemodialysis patients
- Source :
- American journal of nephrology. 22(1)
- Publication Year :
- 2002
-
Abstract
- Although intravenous iron has proved to optimize the efficacy of EPOrHu in hemodialysis patients, hitherto no consensus exists with respect to the best regimen of intravenous iron administration. We started a prospective randomized study in 26 patients undergoing chronic hemodialysis who had adequate iron metabolism indices (serum ferritin >100 µg/l; %TSAT >20%; %HypoE 26 pg) and were in the maintenance phase of EPOrHu administration (target hemoglobin obtained >10 g/dl). All patients were receiving sodium ferric gluconate (Ferrlecit®) intermittently prior to the study and after a 1-month wash-out period where iron was not administered patients were randomized to receive the same previous dose of intravenous iron either in a continuous (6.25–21.3 mg in every hemodialysis session) or an intermittent regimen (62.5 mg every 1–4 weeks, not modifying the previous schedule of administration). At 16 weeks, the continuous group showed a significant increment in serum Hb (11.83 ± 1.12 g/dl) with respect to baseline (10.96 ± 1.31 g/dl) (p < 0.05), whereas no differences were obtained in intermittent group (baseline: 11.16 ± 1.03 g/dl; 16 weeks: 11.14 ± 0.90 g/dl, NS). In contrast with the intermittent group, serum ferritin increased significantly in the continuous group (16 weeks: 508 ± 157 µg/l; baseline: 368 ± 56 µg/l; p < 0.05), whereas %TSAT and CHr did not modified during the study in both groups. %HypoE increased significantly with respect to baseline values in the continuous group (p < 0.05) and close to significantly different in the intermittent group (p = 0.06). Our study suggests that hemodialysis patients in the maintenance phase of EPOrHu administration would obtain further benefit in terms of serum hemoglobin level with a continuous intravenous serum ferric gluconate regimen, at least in the short term.
- Subjects :
- Male
medicine.medical_specialty
Anemia
medicine.medical_treatment
Iron
Sodium ferric gluconate
Ferric Compounds
law.invention
Hemoglobins
Randomized controlled trial
law
Renal Dialysis
medicine
Humans
Prospective Studies
Infusions, Intravenous
Erythropoietin
Aged
Chemotherapy
business.industry
Middle Aged
medicine.disease
Recombinant Proteins
Surgery
Clinical trial
Regimen
Nephrology
Anesthesia
Kidney Failure, Chronic
Female
Hemodialysis
business
medicine.drug
Subjects
Details
- ISSN :
- 02508095
- Volume :
- 22
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- American journal of nephrology
- Accession number :
- edsair.doi.dedup.....e37a74918ed6ba0f6f3360910fb2e526