Effect of fenfluramine on the intestinal absorption of triglycerides

Fenfluramine decreased plasma triglycerides in fed rats but not in fasted rats. When this compound was administered to rats in a post-absorptive state, a diminution in lymphatic flow and in triglyceride concentration was observed. Moreover, pretreatment with fenfluramine inhibited a rise in plasma and lymph triglycerides, normally found after an olive oil load. No alterations were noted in the flow rate and density of bile. The motility of the small intestine was decreased. These data suggest that the lowering of plasma triglycerides, elicited by fenfluramine, is at least partially due to inhibition of the intestianal absorption of triglycerides.