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Contemporary Comparison of Clinicopathologic Characteristics and Survival Outcomes of Prostate Ductal Carcinoma and Acinar Adenocarcinoma: A Population-Based Study

Contemporary Comparison of Clinicopathologic Characteristics and Survival Outcomes of Prostate Ductal Carcinoma and Acinar Adenocarcinoma: A Population-Based Study

Authors :
Felix Preisser
Derya Tilki
Elio Mazzone
Alberto Briganti
Zhe Tian
Pierre I. Karakiewicz
Kevin C. Zorn
Sophie Knipper
Francesco A. Mistretta
Fred Saad
Markus Graefen
Knipper, S.
Preisser, F.
Mazzone, E.
Mistretta, F. A.
Tian, Z.
Briganti, A.
Zorn, K. C.
Saad, F.
Tilki, D.
Graefen, M.
Karakiewicz, P. I.
Source :
Clinical Genitourinary Cancer. 17:231-237.e2
Publication Year :
2019
Publisher :
Elsevier BV, 2019.

Abstract

Purpose To investigate clinicopathologic characteristics and cancer-specific mortality (CSM) rates of ductal carcinoma (DC) versus the common acinar adenocarcinoma in nonmetastatic and metastatic (M1) prostate cancer patients. Patients and Methods Within the Surveillance, Epidemiology, and End Results database (2004-2015), we identified patients with histologically confirmed prostate adenocarcinoma who harbored either DC (n = 581) or acinar adenocarcinoma (n = 489,296). Kaplan-Meier and 4:1 propensity score–matched multivariable Cox regression models adjusted for clinical and pathologic parameters were used to test for CSM differences. Three separate analyses were performed on all patients with nonmetastatic disease, patients with nonmetastatic patients treated with radical prostatectomy only, and patients with metastatic disease. Results DC was identified in 502 (0.10%) of 469,946 patients with nonmetastatic disease and 79 (0.39%) of 19,931 patients with metastatic disease. In patients with nonmetastatic disease, 253 (50.4%) DC patients underwent radical prostatectomy, 61 (12.2%) DC patients received external-beam radiotherapy, and 188 (37.4%) received other treatment modalities. In multivariable analyses, DC was associated with higher CSM in the overall nonmetastatic patient population (hazard ratio [HR] = 1.8; 95% confidence interval [CI], 1.3-2.6; P = .001), in the nonmetastatic radical prostatectomy population (HR = 2.8; 95% CI, 1.3-6.0; P Conclusion Prostate cancers of ductal origin represent a rare entity among patients with nonmetastatic disease as well as among patients with metastatic disease, and regardless of stage, DC behaves more aggressively.

Details

ISSN :
15587673
Volume :
17
Database :
OpenAIRE
Journal :
Clinical Genitourinary Cancer
Accession number :
edsair.doi.dedup.....e36ae2136d596c4cc4f376dbe26717d5
Full Text :
https://doi.org/10.1016/j.clgc.2019.04.009