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Supplementation with carotenoids corrects increased lipid peroxidation in children with cystic fibrosis
- Source :
- The American journal of clinical nutrition. 64(1)
- Publication Year :
- 1996
-
Abstract
- Evidence of lipid peroxidation previously documented in cystic fibrosis (CF) implies an imbalance between free radical generation and antioxidant defense mechanisms. The aim of the present study was to examine the relation between plasma concentrations of malondialdehyde, a marker of lipid peroxidation, and the exogenous antioxidant line of defense. Malondialdehyde concentrations (90.2 +/- 4.7 nmol/L) in 25 children with CF aged 9.6 +/- 0.8 y were higher (P < 0.001) than concentrations (69.1 +/- 2.6 nmol/L) in 17 children used as control subjects and were not correlated with any marker of disease severity. In contrast with their all-rac-alpha-tocopherol status, which was normal as a result of routine supplementation with a 200-mg dose of all-rac-alpha-tocopheryl acetate/d, beta-carotene was very low. A 2-mo open trial in which 12 children with CF aged 11.5 +/- 0.8 y were given 4.42 mg (8.23 mumol) beta-carotene three times per day led to normalization of the malondialdehyde concentration in all but 1 patient, in conjunction with an increase of plasma beta-carotene from 0.08 +/- 0.03 to 3.99 +/- 0.92 mumol/L. Their plasma concentrations were inversely correlated (r = -0.54, P = 0.006) [corrected] with malondialdehyde when the values measured pre- and posttreatment were pooled. We conclude that beta-carotene deficiency contributes to lipid peroxidation in CF and that supplementation may eventually prove to be a useful adjunct for the management of the disease.
- Subjects :
- Vitamin
Adult
Male
medicine.medical_specialty
Antioxidant
Adolescent
Cystic Fibrosis
medicine.medical_treatment
Medicine (miscellaneous)
medicine.disease_cause
Cystic fibrosis
Lipid peroxidation
chemistry.chemical_compound
beta-Carotene
Internal medicine
Malondialdehyde
medicine
Humans
Vitamin E
Child
Carotenoid
chemistry.chemical_classification
Nutrition and Dietetics
Chemistry
medicine.disease
beta Carotene
Carotenoids
Endocrinology
Child, Preschool
Female
Lipid Peroxidation
Oxidative stress
Subjects
Details
- ISSN :
- 00029165
- Volume :
- 64
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The American journal of clinical nutrition
- Accession number :
- edsair.doi.dedup.....e36510b9c1990a5aed1854f8c0abc75c