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Decreased resting-state alpha-band activation and functional connectivity after sleep deprivation

Authors :
Chen Yang
Jintao Wu
Qianxiang Zhou
Jiaxuan Li
Yi Xiao
Shuyu Shao
Source :
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021), Scientific Reports
Publication Year :
2021
Publisher :
Springer Science and Business Media LLC, 2021.

Abstract

BackgroundCognitive abilities are impaired by sleep deprivation and can be recovered when sufficient sleep is obtained. Changes in alpha-band oscillations are considered to be highly related to sleep deprivation. The effect of sleep deprivation on brain activation and functional connectivity in the resting-state alpha band remains unclear. The purpose of this study was to investigate how sleep deprivation and recovery sleep could change resting-state alpha-band neural oscillations.MethodsIn this study, thirty young, healthy participants obtained approximately 8 h of normal sleep, followed by 36 h of sleep deprivation. On the following recovery night, subjects underwent recovery sleep. Resting-state EEG after normal sleep, sleep deprivation and recovery sleep was recorded. Power spectrum, source localization and functional connectivity analyses were used to investigate the changes in resting-state alpha-band activity after normal sleep, sleep deprivation and recovery sleep.ResultsThe results showed that the global alpha power spectrum decreased and source activation was notably reduced in the precuneus, posterior cingulate cortex, cingulate gyrus, and paracentral lobule after sleep deprivation. Functional connectivity analysis after sleep deprivation showed a weakened functional connectivity pattern in a widespread network with the precuneus and posterior cingulate cortex as the key nodes. Furthermore, the changes caused by sleep deprivation were reversed to a certain extent but not significantly after one night of sleep recovery, which may be due to inadequate time for recovery sleep.ConclusionsIn conclusion, large-scale resting-state alpha-band activation and functional connectivity were weakened after sleep deprivation, and the inhibition of default mode network function with the precuneus and posterior cingulate cortex as the pivotal nodes may be an important cause of cognitive impairment. These findings provide new insight into the physiological response of sleep deprivation and determine how sleep deprivation disrupts brain alpha-band oscillations.

Details

ISSN :
20452322
Volume :
11
Database :
OpenAIRE
Journal :
Scientific Reports
Accession number :
edsair.doi.dedup.....e35c95c258f25638f4edd4aa7e02fe87
Full Text :
https://doi.org/10.1038/s41598-020-79816-8