Back to Search
Start Over
Decreased resting-state alpha-band activation and functional connectivity after sleep deprivation
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- BackgroundCognitive abilities are impaired by sleep deprivation and can be recovered when sufficient sleep is obtained. Changes in alpha-band oscillations are considered to be highly related to sleep deprivation. The effect of sleep deprivation on brain activation and functional connectivity in the resting-state alpha band remains unclear. The purpose of this study was to investigate how sleep deprivation and recovery sleep could change resting-state alpha-band neural oscillations.MethodsIn this study, thirty young, healthy participants obtained approximately 8 h of normal sleep, followed by 36 h of sleep deprivation. On the following recovery night, subjects underwent recovery sleep. Resting-state EEG after normal sleep, sleep deprivation and recovery sleep was recorded. Power spectrum, source localization and functional connectivity analyses were used to investigate the changes in resting-state alpha-band activity after normal sleep, sleep deprivation and recovery sleep.ResultsThe results showed that the global alpha power spectrum decreased and source activation was notably reduced in the precuneus, posterior cingulate cortex, cingulate gyrus, and paracentral lobule after sleep deprivation. Functional connectivity analysis after sleep deprivation showed a weakened functional connectivity pattern in a widespread network with the precuneus and posterior cingulate cortex as the key nodes. Furthermore, the changes caused by sleep deprivation were reversed to a certain extent but not significantly after one night of sleep recovery, which may be due to inadequate time for recovery sleep.ConclusionsIn conclusion, large-scale resting-state alpha-band activation and functional connectivity were weakened after sleep deprivation, and the inhibition of default mode network function with the precuneus and posterior cingulate cortex as the pivotal nodes may be an important cause of cognitive impairment. These findings provide new insight into the physiological response of sleep deprivation and determine how sleep deprivation disrupts brain alpha-band oscillations.
- Subjects :
- Adult
Male
0301 basic medicine
Rest
Science
Precuneus
Neurophysiology
Article
Young Adult
03 medical and health sciences
0302 clinical medicine
Gyrus
Neural Pathways
medicine
Humans
Paracentral lobule
Default mode network
Brain Mapping
Multidisciplinary
Resting state fMRI
business.industry
Brain
Cognitive neuroscience
Magnetic Resonance Imaging
Sleep in non-human animals
Sleep deprivation
030104 developmental biology
medicine.anatomical_structure
Posterior cingulate
Sleep Deprivation
Medicine
Circadian rhythms and sleep
medicine.symptom
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....e35c95c258f25638f4edd4aa7e02fe87
- Full Text :
- https://doi.org/10.1038/s41598-020-79816-8