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Ultrafast optical-ultrasonic system and miniaturized catheter for imaging and characterizing atherosclerotic plaques in vivo
- Source :
- Li, Jiawen; Ma, Teng; Mohar, Dilbahar; Steward, Earl; Yu, Mingyue; Piao, Zhonglie; et al.(2015). Ultrafast optical-ultrasonic system and miniaturized catheter for imaging and characterizing atherosclerotic plaques in vivo. Scientific Reports, 5(1). doi: 10.1038/srep18406. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/24x015gf, Scientific Reports
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Atherosclerotic coronary artery disease (CAD) is the number one cause of death worldwide. The majority of CAD-induced deaths are due to the rupture of vulnerable plaques. Accurate assessment of plaques is crucial to optimize treatment and prevent death in patients with CAD. Current diagnostic techniques are often limited by either spatial resolution or penetration depth. Several studies have proved that the combined use of optical and ultrasonic imaging techniques increase diagnostic accuracy of vulnerable plaques. Here, we introduce an ultrafast optical-ultrasonic dual-modality imaging system and flexible miniaturized catheter, which enables the translation of this technology into clinical practice. This system can perform simultaneous optical coherence tomography (OCT)-intravascular ultrasound (IVUS) imaging at 72 frames per second safely in vivo, i.e., visualizing a 72 mm-long artery in 4 seconds. Results obtained in atherosclerotic rabbits in vivo and human coronary artery segments show that this ultrafast technique can rapidly provide volumetric mapping of plaques and clearly identify vulnerable plaques. By providing ultrafast imaging of arteries with high resolution and deep penetration depth simultaneously, this hybrid IVUS-OCT technology opens new and safe opportunities to evaluate in real-time the risk posed by plaques, detect vulnerable plaques and optimize treatment decisions.
- Subjects :
- Pathology
medicine.medical_specialty
Catheters
Radiography
Coronary Artery Disease
Signal-To-Noise Ratio
030204 cardiovascular system & hematology
01 natural sciences
Article
010309 optics
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Optical coherence tomography
In vivo
0103 physical sciences
Medicine and Health Sciences
Animals
Humans
Medicine
Aorta, Abdominal
Ultrasonography, Interventional
Miniaturization
Multidisciplinary
medicine.diagnostic_test
business.industry
Ultrasound
medicine.disease
Coronary Vessels
Plaque, Atherosclerotic
3. Good health
Catheter
Ultrasonic sensor
Rabbits
Tomography
business
Tomography, Optical Coherence
Biomedical engineering
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....e35c03921e6cd3c351f896660fed44e6