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Autophagy and phagocytosis converge for better vision
- Source :
- Autophagy. 10:165-167
- Publication Year :
- 2013
- Publisher :
- Informa UK Limited, 2013.
-
Abstract
- The retinal pigment epithelium (RPE) is a single layer of nonregenerating cells essential to homeostasis in the retina and the preservation of vision. While the RPE perform a number of important functions, 2 essential processes are phagocytosis, which removes the most distal tips of the photoreceptors to support disk renewal, and the visual cycle, which maintains the supply of chromophore for regeneration of photo-bleached visual pigments. We recently reported that these processes are linked by a noncanonical form of autophagy termed LC3-associated phagocytosis (LAP) in which components of the autophagy pathway are co-opted by phagocytosis to recover vitamin A in support of optimal vision. Here we summarize these findings.
- Subjects :
- 11-cis retinal
genetic structures
Phagocytosis
ATG5
Retinal Pigment Epithelium
Biology
Models, Biological
Mice
Autophagy
medicine
Animals
Humans
All trans retinol
Molecular Biology
Vision, Ocular
Retina
Retinal pigment epithelium
Cell Biology
Retinal Photoreceptor Cell Outer Segment
Autophagic Punctum
eye diseases
Cell biology
medicine.anatomical_structure
sense organs
Microtubule-Associated Proteins
Visual phototransduction
Subjects
Details
- ISSN :
- 15548635 and 15548627
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Autophagy
- Accession number :
- edsair.doi.dedup.....e3596c0bec809203102245e985628fe5