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Autoimmune Hepatitis in Children in Eastern Denmark
- Source :
- Journal of Pediatric Gastroenterology & Nutrition. 55:376-379
- Publication Year :
- 2012
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2012.
-
Abstract
- Autoimmune hepatitis (AIH) in childhood is a progressive chronic inflammatory liver disease. The aim of this study was to compare the clinical and biochemical characteristics of 33 paediatric patients diagnosed as having AIH with earlier described cohorts, and to examine the effect of early treatment strategies on the course of disease.A population-based cohort of patients from January 1993 to September 2009 was identified prospectively, and the patient data were collected by a retrospective examination of the files.Twenty-nine patients had type 1 AIH, 2 had type 2, and 2 could not be categorised. Among the 33 children, 16 (48.5%) were girls and 17 (51.5%) were boys. Twenty-three (69.7%) of the patients had symptoms at presentation indistinguishable from acute viral hepatitis, but in 16 (69.6%) of those the liver biopsy showed cirrhosis. Twenty (60.6%) patients were treated with prednisolone and azathioprine at the time of remission, whereas 8 (24.2%) were treated with prednisolone. One (3%) patient did not experience remission during the observation period.The patients in our study appeared similar to previously published cohorts, although a female predominance was not observed. Our data suggest that early treatment including both prednisolone and azathioprine could be more effective than prednisolone alone, even if randomised controlled paediatric studies comparing these 2 different treatment regimens are needed.
- Subjects :
- Liver Cirrhosis
Male
medicine.medical_specialty
Adolescent
Hepatitis, Viral, Human
Biopsy
Denmark
Prednisolone
Azathioprine
Autoimmune hepatitis
Liver disease
Sex Factors
immune system diseases
Sex factors
Internal medicine
Prevalence
medicine
Humans
Prospective Studies
Child
Prospective cohort study
Paediatric patients
medicine.diagnostic_test
business.industry
Gastroenterology
Infant
medicine.disease
digestive system diseases
Hepatitis, Autoimmune
Liver
Child, Preschool
Pediatrics, Perinatology and Child Health
Immunology
Drug Therapy, Combination
Female
business
Immunosuppressive Agents
medicine.drug
Subjects
Details
- ISSN :
- 02772116
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Journal of Pediatric Gastroenterology & Nutrition
- Accession number :
- edsair.doi.dedup.....e34f20af45091d6ae4de172b034291ff