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Memory CD4 + T Lymphocytes in the Gastrointestinal Tract Are a Major Source of Cell-Associated Simian Immunodeficiency Virus in Chronic Nonpathogenic Infection of African Green Monkeys
- Source :
- Journal of Virology. 86:11380-11385
- Publication Year :
- 2012
- Publisher :
- American Society for Microbiology, 2012.
-
Abstract
- Simian immunodeficiency virus (SIV) infection of natural hosts is characterized by nonpathogenic chronic viremia, maintenance of gastrointestinal epithelial barrier integrity, and low numbers of target cells. Assessment of cell-associated virus load in T cell subsets in multiple anatomic compartments of chronically SIV-infected sabeus African green monkeys (AGMs) revealed that gastrointestinal memory CD4 + T lymphocytes are a major source of cell-associated virus and a significant contributor to SIV viremia in AGMs.
- Subjects :
- CD4-Positive T-Lymphocytes
viruses
T cell
Immunology
Simian Acquired Immunodeficiency Syndrome
Viremia
Biology
medicine.disease_cause
Microbiology
Cercopithecus aethiops
Virus
Virology
Chlorocebus aethiops
medicine
Animals
RNA, Messenger
Gastrointestinal tract
virus diseases
Viral Load
Simian immunodeficiency virus
medicine.disease
Gastrointestinal Tract
medicine.anatomical_structure
Insect Science
CD4 Antigens
Pathogenesis and Immunity
Simian Immunodeficiency Virus
African Green Monkey
Immunologic Memory
Viral load
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....e34d7fe1e6daf64560546a379e2489ed