Back to Search
Start Over
A case series of pediatric patients with direct antiglobulin test negative autoimmune hemolytic anemia
- Source :
- Transfusion. 59:2528-2531
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Background The diagnosis of autoimmune hemolytic anemia (AIHA) can be challenging since the direct antiglobulin test (DAT) has been reported to be falsely negative in 3%-11% of cases. In children with anemia, laboratory and/or clinical evidence of hemolysis and a negative DAT, clinicians should consider further specialized testing to confirm AIHA to accurately diagnose and treat this uncommon pediatric entity. Study design and methods A retrospective chart review was undertaken at a large tertiary care academic pediatric hematology practice to describe our experience with DAT-negative AIHA. Results From January 1, 2010 through August 1, 2016, 10 children were described who had clinical and laboratory evidence of AIHA, a negative DAT, and further specialized serologic testing confirming this diagnosis. Conclusion This case series highlights the need for further serologic workup when a child's clinical presentation is highly consistent with AIHA despite a negative DAT.
- Subjects :
- Adult
Male
Pediatrics
medicine.medical_specialty
Adolescent
Anemia
Immunology
030204 cardiovascular system & hematology
Tertiary care
Serology
03 medical and health sciences
0302 clinical medicine
Coombs test
medicine
Humans
Immunology and Allergy
Child
Direct antiglobulin test
Retrospective Studies
medicine.diagnostic_test
business.industry
Infant
Retrospective cohort study
Hematology
medicine.disease
Clinical trial
Coombs Test
Child, Preschool
Female
Anemia, Hemolytic, Autoimmune
Autoimmune hemolytic anemia
business
030215 immunology
Subjects
Details
- ISSN :
- 15372995 and 00411132
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Transfusion
- Accession number :
- edsair.doi.dedup.....e33eb27b9344be12622cd9f213d3a577