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Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression
- Source :
- Breast Cancer Research and Treatment. 131:1003-1012
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- Activation of inflammatory pathways is one plausible mechanism underlying the association between obesity and increased breast cancer risk. However, macrophage infiltration and local biomarkers of inflammation in breast adipose tissue have seldom been studied in association with obesity. Gene expression profiles of normal breast tissue from reduction mammoplasty patients were evaluated by whole genome microarrays to identify patterns associated with obesity status (normal-weight, body mass index (BMI)
- Subjects :
- Adult
Cancer Research
Adolescent
Mammaplasty
Adipose tissue
Inflammation
Biology
medicine.disease_cause
Article
Body Mass Index
Young Adult
Breast cancer
medicine
Cluster Analysis
Humans
Macrophage
Breast
Obesity
skin and connective tissue diseases
CD68
Gene Expression Profiling
Macrophages
Middle Aged
medicine.disease
Gene expression profiling
Adipose Tissue
Gene Expression Regulation
Oncology
Immunology
Cancer research
Immunohistochemistry
Female
medicine.symptom
Carcinogenesis
Biomarkers
Subjects
Details
- ISSN :
- 15737217 and 01676806
- Volume :
- 131
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research and Treatment
- Accession number :
- edsair.doi.dedup.....e33d69b62000f538321035ec95ca66cc