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Pendrin as a regulator of ECF and blood pressure
- Source :
- Eladari, D, Chambrey, R, Frische, S, Vallet, M & Edwards, A 2009, ' Pendrin as a regulator of ECF and blood pressure ', Current Opinion in Nephrology and Hypertension, vol. 18, no. 4, pp. 356-62 . https://doi.org/10.1097/MNH.0b013e32832c91f4
- Publication Year :
- 2009
-
Abstract
- Udgivelsesdato: 2009-Jul PURPOSE OF REVIEW: Abnormal renal sodium handling plays a pivotal role in the pathophysiology of arterial hypertension. Though sodium is present in the diet as a chloride salt, most studies have focused on the renal mechanisms of sodium transport and their regulation, and very few have investigated the impact of chloride. However, strong evidence indicates that chloride may play a very important role in the 'prohypertensive' effects of sodium. RECENT FINDINGS: Several observations indicate that sodium has to be administered as NaCl and not as NaHCO3 to raise arterial blood pressure. Recently, genetic studies have pointed out the critical role of the most distal parts of the nephron in regulating sodium balance and blood pressure. Interestingly, in those segments, the transport of Na+ and Cl- proceeds separately, through different molecules. Recent evidence has demonstrated that an apical Cl-/HCO3- exchanger called pendrin is an absolute requirement for chloride reabsorption in the collecting system, indicating that chloride absorption is not passive and paracellular but is mediated by the intercalated cells. Importantly, pendrin disruption protects mice against mineralocorticoid-induced hypertension and impairs renal adaptation to a low NaCl diet. Moreover, recent findings suggest several mechanisms by which chloride transport might affect NaCl balance and blood pressure. SUMMARY: Pendrin-mediated chloride transport through intercalated cells appears to be an independent and important determinant of renal NaCl handling and therefore might represent a new target for blood pressure control.
- Subjects :
- medicine.medical_specialty
Sodium
chemistry.chemical_element
Blood Pressure
Nephron
Sodium Chloride
Kidney
Chloride
Chlorides
Internal medicine
Extracellular fluid
Internal Medicine
medicine
Animals
Humans
Chloride-Bicarbonate Antiporters
Kidney Tubules, Distal
Ion Transport
biology
Chemistry
Reabsorption
Membrane Transport Proteins
Extracellular Fluid
Pendrin
Nephrons
medicine.anatomical_structure
Endocrinology
Sulfate Transporters
Nephrology
Paracellular transport
biology.protein
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Eladari, D, Chambrey, R, Frische, S, Vallet, M & Edwards, A 2009, ' Pendrin as a regulator of ECF and blood pressure ', Current Opinion in Nephrology and Hypertension, vol. 18, no. 4, pp. 356-62 . https://doi.org/10.1097/MNH.0b013e32832c91f4
- Accession number :
- edsair.doi.dedup.....e33c23da2ed46ed71931c56a3e28b413