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Nature of inhibitory postsynaptic activity in developing relay cells of the lateral geniculate nucleus
- Source :
- Journal of neurophysiology. 90(2)
- Publication Year :
- 2003
-
Abstract
- Using intracellular recordings in an isolated (in vitro) brain stem preparation, we examined the inhibitory postsynaptic responses of developing neurons in the dorsal lateral geniculate nucleus (LGN) of the rat. As early as postnatal day (P) 1–2, 31% of all excitatory postsynaptic (EPSP) activity evoked by electrical stimulation of the optic tract was followed by inhibitory postsynaptic potentials (IPSPs). By P5, 98% of all retinally evoked EPSPs were followed by IPSP activity. During the first postnatal week, IPSPs were mediated largely by GABAA receptors. Additional GABAB-mediated IPSPs emerged at P3–4 but were not prevalent until after the first postnatal week. Experiments involving the separate stimulation of each optic nerve indicated that developing LGN cells were binocularly innervated. At P11–14, it was common to evoke EPSP/IPSP pairs by stimulating either the contralateral or ipsilateral optic nerve. During the third postnatal week, binocular excitatory responses were encountered far less frequently. However, a number of cells still maintained a binocular inhibitory response. These results provide insight about the ontogeny and nature of postsynaptic inhibitory activity in the LGN during the period of retinogeniculate axon segregation.
- Subjects :
- genetic structures
Physiology
Dorsal lateral geniculate nucleus
Lateral geniculate nucleus
Inhibitory postsynaptic potential
Synaptic Transmission
Postsynaptic potential
Animals
Rats, Long-Evans
Visual Pathways
Neurons
Chemistry
General Neuroscience
Excitatory Postsynaptic Potentials
Geniculate Bodies
Neural Inhibition
Receptors, GABA-A
In vitro
Electric Stimulation
Rats
Electrophysiology
nervous system
Animals, Newborn
Receptors, GABA-B
Neuroscience
Intracellular
Subjects
Details
- ISSN :
- 00223077
- Volume :
- 90
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of neurophysiology
- Accession number :
- edsair.doi.dedup.....e31901076655a5522538bc50421c4052