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The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family
- Source :
- Cold Spring Harb Perspect Biol
- Publication Year :
- 2017
-
Abstract
- Interferons (IFNs) are a broad class of cytokines elicited on challenge to the host defense and are essential for mobilizing immune responses to pathogens. Divided into three classes, type I, type II, and type III, all IFNs share in common the ability to evoke antiviral activities initiated by the interaction with their cognate receptors. The nine-member IFN regulatory factor (IRF) family, first discovered in the context of transcriptional regulation of type I IFN genes following viral infection, are pivotal for the regulation of the IFN responses. In this review, we briefly describe cardinal features of the three types of IFNs and then focus on the role of the IRF family members in the regulation of each IFN system.
- Subjects :
- 0301 basic medicine
Context (language use)
DNA
Biology
Viral infection
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Immune system
Gene Expression Regulation
PERSPECTIVES
Interferon
030220 oncology & carcinogenesis
Immunology
Interferon Regulatory Factors
Transcriptional regulation
medicine
Animals
Humans
Interferons
Receptor
Transcription factor
Gene
medicine.drug
Subjects
Details
- ISSN :
- 19430264
- Volume :
- 10
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Cold Spring Harbor perspectives in biology
- Accession number :
- edsair.doi.dedup.....e318e2265781c294c033be45b953fd9c