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In silico modelling of long bone healing involving osteoconduction and mechanical stimulation
- Source :
- Computer Methods in Biomechanics and Biomedical Engineering, Computer Methods in Biomechanics and Biomedical Engineering, 2022, pp.1-13. ⟨10.1080/10255842.2022.2052051⟩
- Publication Year :
- 2022
- Publisher :
- HAL CCSD, 2022.
-
Abstract
- A lot of evidence has shown the importance of stimulating cell mechanically during bone repair. In this study, we modeled the challenging fracture healing of a large bone defect in tibial diaphysis. To fill the fracture gap, we considered the implantation of a porous osteoconductive biomaterial made of poly-lactic acid wrapped by a hydrogel membrane mimicking osteogenic properties of the periosteum. We identified the optimal loading case that best promotes the formation and differentiation into bone tissue. Our results support the idea that a patient's rehabilitation program should be adapted to reproduce optimal mechanical stimulations.
Details
- Language :
- English
- ISSN :
- 10255842 and 14768259
- Database :
- OpenAIRE
- Journal :
- Computer Methods in Biomechanics and Biomedical Engineering, Computer Methods in Biomechanics and Biomedical Engineering, 2022, pp.1-13. ⟨10.1080/10255842.2022.2052051⟩
- Accession number :
- edsair.doi.dedup.....e3112d58b072b9fe0d35af03120ee948