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Pleiotropic Roles of ABC Transporters in Breast Cancer
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 22, Iss 3199, p 3199 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Chemotherapeutics are the mainstay treatment for metastatic breast cancers. However, the chemotherapeutic failure caused by multidrug resistance (MDR) remains a pivotal obstacle to effective chemotherapies of breast cancer. Although in vitro evidence suggests that the overexpression of ATP-Binding Cassette (ABC) transporters confers resistance to cytotoxic and molecularly targeted chemotherapies by reducing the intracellular accumulation of active moieties, the clinical trials that target ABCB1 to reverse drug resistance have been disappointing. Nevertheless, studies indicate that ABC transporters may contribute to breast cancer development and metastasis independent of their efflux function. A broader and more clarified understanding of the functions and roles of ABC transporters in breast cancer biology will potentially contribute to stratifying patients for precision regimens and promote the development of novel therapies. Herein, we summarise the current knowledge relating to the mechanisms, functions and regulations of ABC transporters, with a focus on the roles of ABC transporters in breast cancer chemoresistance, progression and metastasis.
- Subjects :
- Metastatic breast
Antineoplastic Agents
Breast Neoplasms
ATP-binding cassette transporter
Review
Drug resistance
Catalysis
Metastasis
lcsh:Chemistry
Inorganic Chemistry
Structure-Activity Relationship
Breast cancer
medicine
Animals
Humans
metastasis
Neoplasm Metastasis
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
Neoplasm Staging
breast cancer (BC)
business.industry
Organic Chemistry
Transporter
General Medicine
medicine.disease
Computer Science Applications
Gene Expression Regulation, Neoplastic
Multiple drug resistance
Cell Transformation, Neoplastic
lcsh:Biology (General)
lcsh:QD1-999
Drug Resistance, Neoplasm
Multigene Family
Disease Progression
Cancer research
ATP-Binding Cassette Transporters
Female
Disease Susceptibility
ABC transporter
Efflux
multidrug resistance (MDR)
business
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....e2e2532d69979118d44a9f72549538c0